Computational models in cardiology

SA Niederer, J Lumens, NA Trayanova - Nature reviews cardiology, 2019 - nature.com
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Computational modeling of the human atrial anatomy and electrophysiology

O Dössel, MW Krueger, FM Weber, M Wilhelms… - Medical & biological …, 2012 - Springer
This review article gives a comprehensive survey of the progress made in computational
modeling of the human atria during the last 10 years. Modeling the anatomy has emerged …

Three‐dimensional integrated functional, structural, and computational mapping to define the structural “fingerprints” of heart‐specific atrial fibrillation drivers in human …

J Zhao, BJ Hansen, Y Wang, TA Csepe… - Journal of the …, 2017 - Am Heart Assoc
Background Structural remodeling of human atria plays a key role in sustaining atrial
fibrillation (AF), but insufficient quantitative analysis of human atrial structure impedes the …

Simulating human cardiac electrophysiology on clinical time-scales

S Niederer, L Mitchell, N Smith, G Plank - Frontiers in physiology, 2011 - frontiersin.org
In this study, the feasibility of conducting in silico experiments in near-realtime with
anatomically realistic, biophysically detailed models of human cardiac electrophysiology is …

Mathematical approaches to understanding and imaging atrial fibrillation: significance for mechanisms and management

NA Trayanova - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained arrhythmia in humans. The mechanisms
that govern AF initiation and persistence are highly complex, of dynamic nature, and involve …

Personalization of atrial anatomy and electrophysiology as a basis for clinical modeling of radio-frequency ablation of atrial fibrillation

MW Krueger, G Seemann, K Rhode… - IEEE transactions on …, 2012 - ieeexplore.ieee.org
Multiscale cardiac modeling has made great advances over the last decade. Highly detailed
atrial models were created and used for the investigation of initiation and perpetuation of …

Mechanisms for the termination of atrial fibrillation by localized ablation: computational and clinical studies

WJ Rappel, JAB Zaman… - Circulation: Arrhythmia and …, 2015 - Am Heart Assoc
Background—Human atrial fibrillation (AF) can terminate after ablating localized regions,
which supports the existence of localized rotors (spiral waves) or focal drivers. However, it is …

How computer simulations of the human heart can improve anti‐arrhythmia therapy

NA Trayanova, KC Chang - The Journal of physiology, 2016 - Wiley Online Library
Over the last decade, the state‐of‐the‐art in cardiac computational modelling has
progressed rapidly. The electrophysiological function of the heart can now be simulated with …

[HTML][HTML] Echocardiogram-based ventricular isogeometric cardiac analysis using multi-patch fitted NURBS

R Willems, L Verberne, O van der Sluis… - Computer Methods in …, 2024 - Elsevier
Monitoring the cardiac function often relies on non-invasive vital measurements,
electrocardiograms, and low-resolution echocardiograms. The monitoring data can be …

Patient-specific identification of atrial flutter vulnerability–a computational approach to reveal latent reentry pathways

A Loewe, E Poremba, T Oesterlein, A Luik… - Frontiers in …, 2019 - frontiersin.org
Atypical atrial flutter (AFlut) is a reentrant arrhythmia which patients frequently develop after
ablation for atrial fibrillation (AF). Indeed, substrate modifications during AF ablation can …