Electro-organic synthesis–a 21 st century technique

D Pollok, SR Waldvogel - Chemical science, 2020 - pubs.rsc.org
The severe limitations of fossil fuels and finite resources influence the scientific community to
reconsider chemical synthesis and establish sustainable techniques. Several promising …

From protein film electrochemistry to nanoconfined enzyme cascades and the electrochemical leaf

FA Armstrong, B Cheng, RA Herold… - Chemical …, 2022 - ACS Publications
Protein film electrochemistry (PFE) has given unrivalled insight into the properties of redox
proteins and many electron-transferring enzymes, allowing investigations of otherwise ill …

The power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades

G Morello, CF Megarity, FA Armstrong - Nature communications, 2021 - nature.com
Multistep enzyme-catalyzed cascade reactions are highly efficient in nature due to the
confinement and concentration of the enzymes within nanocompartments. In this way, rates …

A nanoconfined four-enzyme cascade simultaneously driven by electrical and chemical energy, with built-in rapid, confocal recycling of NADP (H) and ATP

CF Megarity, TRI Weald, RS Heath, NJ Turner… - ACS …, 2022 - ACS Publications
The importance of energized nanoconfinement for facilitating the study and execution of
enzyme cascades that feature multiple exchangeable cofactors is demonstrated by …

One-pot bioelectrocatalytic conversion of chemically inert hydrocarbons to imines

H Chen, T Tang, CA Malapit, YS Lee… - Journal of the …, 2022 - ACS Publications
Petroleum hydrocarbons are our major energy source and an important feedstock for the
chemical industry. With the exception of combustion, the deep conversion of chemically inert …

Exploiting bidirectional electrocatalysis by a nanoconfined enzyme cascade to drive and control enantioselective reactions

L Wan, RS Heath, CF Megarity, AJ Sills, RA Herold… - ACS …, 2021 - ACS Publications
The ability to drive and observe rapid enzyme catalysis in both directions is an important and
natural consequence of immobilizing cascade components within electrode nanopores and …

Efficient Electrocatalytic CO2 Fixation by Nanoconfined Enzymes via a C3-to-C4 Reaction That Is Favored over H2 Production

G Morello, B Siritanaratkul, CF Megarity… - ACS …, 2019 - ACS Publications
Reduction of CO2 and its direct entry into organic chemistry is achieved efficiently and in a
highly visible way using a metal oxide electrode in which two enzyme catalysts, one for …

Progress in Scaling up and Streamlining a Nanoconfined, Enzyme‐Catalyzed Electrochemical Nicotinamide Recycling System for Biocatalytic Synthesis

B Cheng, L Wan, FA Armstrong - ChemElectroChem, 2020 - Wiley Online Library
An electrochemically driven nicotinamide recycling system, referred to as the
'electrochemical leaf'has unique attributes that may suit it to the small‐scale industrial …

Electrified nanoconfined biocatalysis with rapid cofactor recycling

CF Megarity, B Siritanaratkul, B Cheng… - …, 2019 - Wiley Online Library
In living cells, the overall rates of catalytic reaction chains (cascades) are massively
enhanced by nanoconfinement of enzymes in tiny enclosed volumes: presented in such a …

Exploiting electrode nanoconfinement to investigate the catalytic properties of isocitrate dehydrogenase (IDH1) and a cancer-associated variant

RA Herold, R Reinbold, CF Megarity… - The Journal of …, 2021 - ACS Publications
Human isocitrate dehydrogenase (IDH1) and its cancer-associated variant (IDH1 R132H)
are rendered electroactive through coconfinement with a rapid NADP (H) recycling enzyme …