Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …
Therapeutically harnessing extracellular vesicles
The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …
from the study of fundamental biology to a subject of significant clinical relevance. The …
Extracellular vesicles as a next-generation drug delivery platform
IK Herrmann, MJA Wood, G Fuhrmann - Nature nanotechnology, 2021 - nature.com
Extracellular-vesicle-based cell-to-cell communication is conserved across all kingdoms of
life. There is compelling evidence that extracellular vesicles are involved in major (patho) …
life. There is compelling evidence that extracellular vesicles are involved in major (patho) …
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Extracellular vesicles and exomere nanoparticles are under intense investigation as sources
of clinically relevant cargo. Here we report the discovery of a distinct extracellular …
of clinically relevant cargo. Here we report the discovery of a distinct extracellular …
Molecular biomarkers in cancer
VK Sarhadi, G Armengol - Biomolecules, 2022 - mdpi.com
Molecular cancer biomarkers are any measurable molecular indicator of risk of cancer,
occurrence of cancer, or patient outcome. They may include germline or somatic genetic …
occurrence of cancer, or patient outcome. They may include germline or somatic genetic …
Extracellular vesicles in immunomodulation and tumor progression
Extracellular vesicles have emerged as prominent regulators of the immune response
during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a …
during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a …
Metal–organic framework-functionalized paper-based electrochemical biosensor for ultrasensitive exosome assay
X Liu, X Gao, L Yang, Y Zhao, F Li - Analytical chemistry, 2021 - ACS Publications
The exosome has emerged as a promising noninvasive biomarker for the early diagnosis of
cancer. Therefore, it is highly desirable to develop simple, inexpensive, and user-friendly …
cancer. Therefore, it is highly desirable to develop simple, inexpensive, and user-friendly …
[HTML][HTML] Nasopharyngeal carcinoma ecology theory: Cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem
W Luo - Theranostics, 2023 - ncbi.nlm.nih.gov
Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer that is generally
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …
The evolving translational potential of small extracellular vesicles in cancer
Cancer-derived extracellular vesicles (EVs) are regarded as having promising potential to
be used as therapeutics and disease biomarkers. Mechanistically, EVs have been shown to …
be used as therapeutics and disease biomarkers. Mechanistically, EVs have been shown to …
Engineered drug-loaded cellular membrane nanovesicles for efficient treatment of postsurgical cancer recurrence and metastasis
Cancer recurrence and metastasis are still common causes of postsurgery death in patients
with solid tumors, suggesting that additional consolidation therapeutic strategies are …
with solid tumors, suggesting that additional consolidation therapeutic strategies are …