Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

Type I interferons (IFNs) facilitate cancer immunosurveillance, antitumor immunity and
antitumor efficacy of conventional cell death-inducing therapies (chemotherapy/radiotherapy …

Recent evidence suggests that NK cells require priming to display full effector activity. In this
study, we demonstrate that IL-18 contributed to this phenomenon. IL-18 signaling-deficient …

Sensing invading pathogens early in infection is critical for establishing host defense. Two
cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) …

Upon pathogen detection, the innate immune system triggers signaling events leading to
upregulation of pro-inflammatory and anti-microbial mRNA transcripts. RNA-binding proteins …

In this review we discuss specific examples of regulation of cytokine genes and focus on a
new mechanism involving post-transcriptional regulation via miRNAs. The post …

Simple Summary The crucial immune stimulatory functions exerted by Type I Interferons
(IFNs) in cancer settings have been not only widely demonstrated during the last fifty years …

There is a clear need for novel, effective therapeutic approaches to hemorrhagic fever due to
filoviruses. Ebola virus hemorrhagic fever is associated with robust interferon (IFN)–α …

ARED Organism represents the expansion of the adenylate uridylate (AU)-rich element
(ARE)-containing human mRNA database into the transcriptomes of mouse and rat. As a …

Tristetraprolin (TTP) regulates expression at the level of mRNA decay of several cytokines,
including the T cell-specific cytokine, interleukin-2. We performed experiments to determine …