The NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) transcription factor
family is a pleiotropic regulator of many cellular signaling pathways, providing a mechanism …

Different animal and human studies from last two decades in the case of Parkinson's
disease (PD) have concentrated on oxidative stress due to increased inflammation and …

The human microbiome consists of~ 3.8× 1013 symbiotic microorganisms that form a highly
complex and dynamic ecosystem: the gastrointestinal (GI) tract constitutes the largest …

Drosophila NF-κB homologue “dorsal” is required for establishment of dorso-ventral polarity
in the developing embryo (7). In the developing rat nervous system, levels of NF-κB activity …

Ischemic stroke triggers lipid peroxidation and neuronal injury. Docosahexaenoic acid
released from membrane phospholipids during brain ischemia is a major source of lipid …

Here we review evidence of roles for NF-κB in the regulation of developmental and synaptic
plasticity, and cell survival in physiological and pathological settings. Signaling pathways …

The transcription factor NF-κB has diverse functions in the nervous system, depending on
the cellular context. NF-κB is constitutively activated in glutamatergic neurons. Knockout of …

Human cerebrospinal fluid (CSF), produced by the choroid plexus and secreted into the
brain ventricles and subarachnoid space, plays critical roles in intra-cerebral transport and …

Alterations in transcription, RNA editing, translation, protein processing, and clearance are a
consistent feature of Alzheimer's disease (AD) brain. To extend our initial study (Alzheimer …

A direct relationship exists between aging and increasing incidences of chronic diseases. In
fact, with most age-associated diseases individuals manifest an underlying chronic …