[HTML][HTML] Inhibition of GCN2 Reveals Synergy with Cell-Cycle Regulation and Proteostasis
The integrated stress response is a signaling network comprising four branches, each
sensing different cellular stressors, converging on the phosphorylation of eIF2α to …
sensing different cellular stressors, converging on the phosphorylation of eIF2α to …
Stanniocalcin 2 governs cancer cell adaptation to nutrient insufficiency through alleviation of oxidative stress
S Qie, H Xiong, Y Liu, C Yan, Y Wang, L Tian, C Wang… - 2024 - researchsquare.com
Solid tumours often endure nutrient insufficiency during progression. How tumour cells
adapt to temporal and spatial nutrient insufficiency remains unclear. We previously identified …
adapt to temporal and spatial nutrient insufficiency remains unclear. We previously identified …
Temozolomide-induced glioma cytotoxicity is enhanced by inhibition of Sirt7, which is involved in growth and progression and is regulated by miR-148a-3p
J Wang, K Sun, G Cheng, H Li, W Lv, L Liang, M Gao… - 2024 - researchsquare.com
Background Glioma is a highly malignant primary nervous system tumor. Temozolomide
(TMZ) is a commonly used chemotherapy drug, but drug resistance is increasing. Therefore …
(TMZ) is a commonly used chemotherapy drug, but drug resistance is increasing. Therefore …