While global metabolic profiling (untargeted metabolomics) has been the center of much
interest and research activity in the past few decades, more recently targeted metabolomics …

Introduction: Tryptophan is the precursor of kynurenine pathway (KP) metabolites which
regulate immune tolerance, energy metabolism, and vascular tone. Since these processes …

Our objective was to determine the amniotic fluid–derived exosomal proteomic profile in
patients who had spontaneous preterm birth (PTB) or preterm premature rupture of …

Spontaneous preterm birth (sPTB) is a leading cause of maternal and neonatal morbidity
and mortality, yet its prevention and early risk stratification are limited. Previous …

The paper presents an LC-MS/MS-based approach to targeted screening of both polar and
non-polar metabolites using a synthesized monolithic column which is a copolymer of …

Preterm birth (PTB) is a leading cause of morbidity and mortality in young children. Infection
is a major cause of this adverse outcome, particularly in PTBs characterised by spontaneous …

Pregnancy is a complicated and insidious state with various aspects to consider, including
the well-being of the mother and child. Developing better non-invasive tests that cover a …

Infectious diseases and cancers are leading causes of death and pose major challenges to
public health. The human peptidome encompasses millions of compounds that display an …

Introduction Most known risk factors for preterm birth, a leading cause of infant morbidity and
mortality, are not modifiable. Advanced molecular techniques are increasingly being applied …

Background In comparison to the non-pregnant state, the first trimester of pregnancy is
characterized by systemic adaptation of the mother. The extent to which these adaptive …