NUT carcinoma (NC) is a rare, aggressive subtype of squamous cell carcinoma defined by
rearrangement of the NUTM1 (aka NUT) gene. NC is driven by NUT‐fusion oncoproteins …

NUT carcinoma, also known as NUT midline carcinoma, is an aggressive malignancy mainly
affecting the midline structures of younger patients and almost invariably leading to death …

NUT midline carcinoma (NMC) is an aggressive subtype of squamous cell carcinoma that
typically harbors BRD4/3–NUT fusion oncoproteins that block differentiation and maintain …

NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most
aggressive human solid malignancies known. NMC is driven by the creation of a …

NUT midline carcinoma is an aggressive tumor that occurs mainly in the head and neck and,
less frequently, the mediastinum and lung. Following identification of an index case of a …

To investigate the mechanism that drives dramatic mistargeting of active chromatin in NUT
midline carcinoma (NMC), we have identified protein interactions unique to the BRD4–NUT …

BRD4-NUT, a driver fusion mutant in rare and highly aggressive NUT carcinoma, acts in
aberrant transcription of anti-differentiation genes by recruiting histone acetyltransferase …

Nuclear protein in testis (NUT) carcinoma is a rare, highly aggressive, poorly differentiated
carcinoma occurring mostly in adolescents and young adults. This tumor usually arises from …

Acetylation of lysines on nucleosomal histones has long been perceived as being
responsible for weakening DNA− histone interactions, thereby influencing gene …

BET proteins have recently become recognized for their role in a broad range of cancers
and are defined by the presence of two acetyl-histone reading bromodomains and an ET …