Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has
been developed and employed in multiple clinical imaging research centers worldwide …

Cancer cells are characterized by a metabolic shift in cellular energy production,
orchestrated by the transcription factor HIF-1α, from mitochondrial oxidative phosphorylation …

Contrast-enhanced magnetic resonance imaging (MRI) is an indispensable tool for
diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI …

The vast majority of cancers exhibit increased glucose uptake and glycolysis regardless of
oxygen availability. This metabolic shift leads to an enhanced production of lactic acid that …

Extracellular pH (pH e) decrease is associated with tumor growth, invasion, metastasis, and
chemoresistance, which can be detected by chemical exchange saturation transfer (CEST) …

Chemical exchange saturation transfer (CEST) imaging is a novel contrast mechanism,
relying on the exchange between mobile protons in amide (-NH), amine (-NH 2) and …

Purpose We optimized acido-chemical exchange saturation transfer (acidoCEST) magnetic
resonance imaging (MRI), a method that measures extracellular pH (pHe), and translated …

Purpose In this study, we aimed to use 3T magnetic resonance imaging (MRI), which is
clinically available, to determine the extracellular pH (pHe) of liver tumors and prospectively …

Acidosis within tumor and kidney tissues has previously been quantitatively measured using
a molecular imaging technique known as acidoCEST MRI. The previous studies used …

Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo
metabolites changes or characterizing the tumor microenvironment, non-invasive imaging …