Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

The APOE4 protein affects the primary neuropathological markers of Alzheimer's disease
(AD): amyloid plaques, neurofibrillary tangles, and gliosis. These interactions have been …

Alzheimer's disease (AD) is the most common neurodegenerative disorder with obscure
pathogenesis and no disease-modifying therapy to date. AD is multifactorial disease that …

Lipid droplets (LDs) serve as energy rich reservoirs and have been associated with
apolipoprotein E (APOE) and neurodegeneration. The E4 allele of APOE (E4) is the …

Objective To test the hypothesis that ApoE isoforms affect mitochondrial structure and
function that are related to cognitive impairment in Alzheimer disease (AD), we …

With age, our cognitive skills and abilities decline. Maybe starting as an annoyance, this
decline can become a major impediment to normal daily life. Recent research shows that the …

Synaptic plasticity is believed to underlie the cellular and molecular basis of memory
formation. Mitochondria are one of the main organelles involved in metabolism and energy …

Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk.
APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD. The AD risk …

Background Wide evidence suggests that physical activity (PA) confers protection against
Alzheimer's disease (AD). On the other hand, the apolipoprotein E gene (APOE) ε4 allele …