Proteins of the intermediate filament (IF) supergene family are ubiquitous structural
components that comprise, in a cell type–specific manner, the cytoskeleton proper in animal …

The nuclear lamina is a nuclear peripheral meshwork that is mainly composed of nuclear
lamins, although a small fraction of lamins also localizes throughout the nucleoplasm …

The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

The lamins are the major architectural proteins of the animal cell nucleus. Lamins line the
inside of the nuclear membrane, where they provide a platform for the binding of proteins …

Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …

The premature aging disease Hutchinson–Gilford Progeria Syndrome (HGPS) is caused by
a mutant lamin A (LAΔ50). Nuclei in cells expressing LAΔ50 are abnormally shaped and …

The nuclear lamins are type V intermediate filament proteins that are critically important for
the structural properties of the nucleus. In addition, they are involved in the regulation of …

Mutations in lamins, which are ubiquitous nuclear intermediate filaments, lead to a variety of
disorders including muscular dystrophy and dilated cardiomyopathy. Lamins provide …

It has been demonstrated that nuclear lamins are important proteins in maintaining cellular
as well as nuclear integrity, and in maintaining chromatin organization in the nucleus …

Intermediate filaments (IFs) are major constituents of the cytoskeleton and nuclear boundary
in animal cells. They are of prime importance for the functional organization of structural …