The importance of nutrition in human health has been understood for over a century.
However, debate is ongoing regarding the role of added and free sugars in physiological …

Obesity is defined as abnormal and excessive fat accumulation, and it is a risk factor for
developing metabolic and neurodegenerative diseases and cognitive deficits. Obesity is …

Cognitive decline covers a broad spectrum of disorders, not only resulting from brain
diseases but also from systemic diseases, which seriously influence the quality of life and …

In recent decades, traditional eating habits have been replaced by a more globalized diet,
rich in saturated fatty acids and simple sugars. Extensive evidence shows that these dietary …

Alzheimer's disease (AD) is the most common form of dementia. Obesity in middle age
increases AD risk and severity, which is alarming given that obesity prevalence peaks at …

Background: Obesity constitutes a risk factor for cognitive impairment. In rodent models, long-
term exposure to obesogenic diets leads to hippocampal taurine accumulation. Since …

Obesity and ageing predispose to numerous, yet overlapping chronic diseases. For
example, metabolic abnormalities, including insulin resistance (IR) and type 2 diabetes …

Background: Severe obesity may be accompanied by cognitive dysfunction and NAFLD, but
the associations remain unclear. We describe the prevalence and features of cognitive …

Familial hypercholesterolemia (FH) is a metabolic condition caused mainly by a mutation in
the low-density lipoprotein (LDL) receptor gene (LDLR), which is highly prevalent in the …

Dietary restriction of the essential amino acid, methionine, has been shown to induce unique
metabolic protection. The peripheral benefits of methionine restriction (MR) are well …