This review provides a comprehensive overview of the functional roles of disulfide bonds
and their relevance to human disease. The critical roles of disulfide bonds in protein …

Sexual reproduction in angiosperms relies on precise communications between the pollen
and pistil. The molecular mechanisms underlying these communications remain elusive. We …

Abstract N 6-methyladenosine (m6A) is the most abundant ribonucleotide modification
among eukaryotic messenger RNAs. The m6A “writer” consists of the catalytic subunit m6A …

We describe pLink 2, a search engine with higher speed and reliability for proteome-scale
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …

Disulfide bonds are important structural moieties of proteins: they ensure proper folding,
provide stability, and ensure proper function. With the increasing use of proteins for …

The voltage-gated calcium (Cav) channels convert membrane electrical signals to
intracellular Ca2+-mediated events. Among the ten subtypes of Cav channel in mammals …

Odorants are detected as smell in the nasal epithelium of mammals by two G-protein-
coupled receptor families, the odorant receptors and the trace amine-associated …

Disulfides are widely found in natural products and find a wide range of applications in life
sciences, materials chemistry and other fields. The preparation of disulfides mainly rely on …

Sexual reproduction requires recognition between the male and female gametes. In
flowering plants, the immobile sperms are delivered to the ovule-enclosed female …

Liver fibrosis is a very common condition seen in millions of patients with various liver
diseases, and yet no effective treatments are available owing to poorly characterized …