Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Urban-living individuals are exposed to many environmental factors that may combine and
interact to influence mental health. While individual factors of an urban environment have …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Most genome-wide association studies (GWAS) of major depression (MD) have been
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …

Over the past decade, the role of the 14–3-3 protein has received increasing interest. Seven
subtypes of 14–3-3 proteins exhibit high homology; however, each subtype maintains its …

The neurobiological bases of mood instability are poorly understood. Neuronal network
alterations and neurometabolic abnormalities have been implicated in the pathophysiology …

Anorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly
comorbid psychiatric disorders and related traits. Although significant genetic correlations …

Personality is influenced by both genetic and environmental factors and is associated with
other psychiatric traits such as anxiety and depression. The 'big five'personality traits, which …

Chronic pain is highly prevalent worldwide and imparts a significant socioeconomic and
public health burden. Factors influencing susceptibility to, and mechanisms of, chronic pain …

Mitochondrial dysfunction was highlighted as a crucial vulnerability factor for the
development of depression. However, systemic studies assessing stress-induced changes …