Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

Sheppard, David N., and Michael J. Welsh. Structure and Function of the CFTR Chloride
Channel. Physiol. Rev. 79, Suppl.: S23–S45, 1999.—The cystic fibrosis transmembrane …

CYSTIC fibrosis is associated with a defect in epithelial chloride ion transport (reviewed in
refs 1, 2) which is caused by mutations in a membrane protein called CFTR (cystic fibrosis …

Circumstantial evidence has accumulated suggesting that CFTR is a regulated low-
conductance Cl-channel. To test this postulate directly, we have purified to homogeneity a …

CHLORIDE channels have several functions, including the regulation of cell volume1, 2,
stabilizing membrane potential3, 4, signal transduction5, 6 and transepithelial transport7 …

Embryonic spinal motor neurons are thought to depend for survival on unidentified factors
secreted both by their peripheral targets and by cells within the central nervous system1 …

Abstract A CYCLIC AMP-stimulated choride conductance appears when the cystic fibres is
gene is expressed in non-epithelial cells by infection with recombinant viruses1, 2. Cyclic …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic
fibrosis. In order to evaluate its function, CFTR was expressed in HeLa, Chinese hamster …

The nature of involvement of the cystic fibrosis gene product (CFTR) in epithelial anion
transport is not yet understood. We have expressed CFTR in Sf9 insect cells using the …

The gene mutated in cystic fibrosis codes for the cystic fibrosis transmembrane conductance
regulator (CFTR), a cyclic AMP-activated chloride channel thought to be critical for salt and …