Antimicrobial and anti-virulence activities of 4-shogaol from grains of paradise against gram-negative bacteria: Integration of experimental and computational methods

AE Koshak, HM Okairy, MA Elfaky, HM Abdallah… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Bacterial resistance to antibiotics is a growing global
concern, highlighting the urgent need for new antimicrobial candidates. Aframomum …

A review on recent analytical methodologies developed for the micro-determination of piperacillin in different matrices

I Eman, EK Fahmy, SE Esmaeel, HA Elkattawy… - Microchemical …, 2024 - Elsevier
Piperacillin belongs to a semisynthetic group of penicillins called ureidopenicillin that have
been developed to have antipseudomonal broad spectrum activity to be used in the …

Cilostazol is a promising anti-pseudomonal virulence drug by disruption of quorum sensing

MW Al-Rabia, HZ Asfour, NA Alhakamy, MA Bazuhair… - AMB Express, 2024 - Springer
Resistance to antibiotics is a critical growing public health problem that desires urgent action
to combat. To avoid the stress on bacterial growth that evokes the resistance development …

Thymoquinone is a natural antibiofilm and pathogenicity attenuating agent in Pseudomonas aeruginosa

MW Al-Rabia, HZ Asfour, NA Alhakamy… - Frontiers in Cellular …, 2024 - frontiersin.org
Pseudomonas aeruginosa belongs to the critical pathogens that represent a global public
health problem due to their high rate of resistance as listed by WHO. P. aeruginosa can …

Investigating Sulforaphane's anti-virulence and anti-quorum sensing properties against Pseudomonas aeruginosa

MM Bendary, MAM Ali, AS Abdel Halim… - Frontiers in …, 2024 - frontiersin.org
Background P. aeruginosa, a significant bacterium, can cause severe illness and resistance
to antibiotics. Quorum sensing (QS) systems regulate virulence factors production. Targeting …

Redirecting pantoprazole as a metallo-beta-lactamase inhibitor in carbapenem-resistant Klebsiella pneumoniae

WH Abdulaal, NA Alhakamy, AH Asseri… - Frontiers in …, 2024 - frontiersin.org
The development of resistance to carbapenems in Klebsiella pneumoniae due to the
production of metallo-β-lactamases (MBLs) is a critical public health problem because …

Honokiol from Magnolia Tree Exhibits Antibacterial and Anti-virulence Potential against Pseudomonas aeruginosa

MA Elfaky, AE Koshak, MF Radwan… - Arabian Journal for …, 2024 - Springer
Pseudomonas aeruginosa is one of the most significant opportunistic infections in clinical
setting and acquires resistance to diverse antibiotics. Honokiol (HON) is a natural bioactive …

6-Paradol exhibits antimicrobial, anti-quorum sensing and anti-virulence capacities on gram-negative bacteria: In vitro and in vivo studies

HM Okairy, AE Koshak, MA Elfaky, HM Abdallah… - South African Journal of …, 2024 - Elsevier
Grains of paradise, which are native to Africa, contain 6-paradol, an antibacterial compound
found in plants of the Zingiberaceae family. In this study, the antimicrobial and anti-virulence …

Utilization of zein nano-based system for promoting antibiofilm and anti-virulence activities of curcumin against Pseudomonas aeruginosa

SM Badr-Eldin, HM Aldawsari, OAA Ahmed… - Nanotechnology …, 2024 - degruyter.com
Bacterial biofilms contribute to increased pathogenesis and bacterial resistance. Biofilms
can enhance pathogenicity by shielding bacteria from the immune system and antibiotics …

Piceatannol: a renaissance in antibacterial innovation unveiling synergistic potency and virulence disruption against serious pathogens

AE Koshak, MA Elfaky, DAI Albadawi… - International …, 2024 - Springer
In the relentless battle against multi-drug resistant Gram-negative bacteria, piceatannol
emerges as a beacon of hope, showcasing unparalleled antibacterial efficacy and a unique …