Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

The WNT–β-catenin system is an evolutionary conserved signalling pathway that is of
particular importance for morphogenesis and cell organization during embryogenesis. The …

Kidney failure is frequently observed during and after COVID-19, but it remains elusive
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …

Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half …

Kidney fibrosis is a common histological manifestation of functional decline in the kidney.
Fibrosis is a reactive process that develops in response to excessive epithelial injury and …

Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney
disease (CKD), suggesting intimate communication between the two types of cells …

Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM),
leading to destruction of normal kidney architecture and loss of renal function. The activation …

Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs)
belong to the metzincin family of zinc-containing multidomain molecules, and can act as …

The Wnt/β-catenin signaling cascade is an evolutionarily conserved, highly complex
pathway that is known to be involved in kidney injury and repair after a wide variety of …

Tubulointerstitial fibrosis, tubular atrophy, and peritubular capillary rarefaction are major
hallmarks of chronic kidney disease. The tubulointerstitium consists of multiple cell …