Modeling cholesterol metabolism and atherosclerosis

MT Mc Auley - WIREs Mechanisms of Disease, 2022 - Wiley Online Library
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and
mortality among Western populations. Many risk factors have been identified for ASCVD; …

Hyperbolic reformulation of a 1D viscoelastic blood flow model and ADER finite volume schemes

GI Montecinos, LO Müller, EF Toro - Journal of Computational Physics, 2014 - Elsevier
The applicability of ADER finite volume methods to solve hyperbolic balance laws with stiff
source terms in the context of well-balanced and non-conservative schemes is extended to …

Bifurcation and dynamics in a mathematical model of early atherosclerosis: How acute inflammation drives lesion development

AD Chalmers, A Cohen, CA Bursill… - Journal of mathematical …, 2015 - Springer
We present here a mathematical model describing the primary mechanisms that drive the
early stages of atherosclerosis. This involves the interactions between modified low density …

Demyelination patterns in a mathematical model of multiple sclerosis

MC Lombardo, R Barresi, E Bilotta, F Gargano… - Journal of mathematical …, 2017 - Springer
In this paper we derive a reaction-diffusion-chemotaxis model for the dynamics of multiple
sclerosis. We focus on the early inflammatory phase of the disease characterized by …

Advection-diffusion-reaction equations: hyperbolization and high-order ADER discretizations

EF Toro, GI Montecinos - SIAM Journal on Scientific Computing, 2014 - SIAM
The purpose of this paper is twofold. First, we extend the applicability of Cattaneo's
relaxation approach, one of the currently known relaxation approaches, to reformulate time …

Reformulations for general advection–diffusion–reaction equations and locally implicit ADER schemes

GI Montecinos, EF Toro - Journal of Computational Physics, 2014 - Elsevier
Following Cattaneo's original idea, in this article we first present two relaxation formulations
for time-dependent, non-linear systems of advection–diffusion–reaction equations. Such …

[PDF][PDF] A scale conjugate neural network learning process for the nonlinear malaria disease model

M Alqhtani, J Gómez-Aguilar, KM Saad, Z Sabir… - AIMS Math, 2023 - aimspress.com
A scale conjugate neural network learning process for the nonlinear malaria disease model
Page 1 AIMS Mathematics, 8(9): 21106–21122. DOI: 10.3934/math.20231075 Received: 15 …

Mathematical modeling of atherosclerotic plaque destabilization: Role of neovascularization and intraplaque hemorrhage

M Guo, Y Cai, X Yao, Z Li - Journal of theoretical biology, 2018 - Elsevier
Observational studies have identified angiogenesis from the adventitial vasa vasorum and
intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and …

Convergence analysis for forward and inverse problems in singularly perturbed time-dependent reaction-advection-diffusion equations

D Chaikovskii, Y Zhang - Journal of Computational Physics, 2022 - Elsevier
In this paper, by employing the asymptotic expansion method, we prove the existence and
uniqueness of a smoothing solution for a time-dependent nonlinear singularly perturbed …

Coupled modeling of lipid deposition, inflammatory response and intraplaque angiogenesis in atherosclerotic plaque

M Guo, Y Cai, C He, Z Li - Annals of Biomedical Engineering, 2019 - Springer
We propose a multiphysical mathematical model by fully coupling lipid deposition,
monocytes/macrophages recruitment and angiogenesis to investigate the …