Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

The giant protein titin forms a unique filament network in cardiomyocytes, which engages in
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …

The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein
titin, which is a scaffolding filament, signaling platform, and provider of passive tension and …

Non‐technical summary Muscle spasticity, due to an upper motoneuron lesion, often leads
to muscle contractures that limit range of motion and cause increased muscle stiffness …

The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and
contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and …

Titin is a giant vertebrate striated muscle protein with critical importance for myofibril
elasticity and structural integrity. We show here that the complete sequence of the human …

The sarcomere contains, in addition to thin and thick filaments, a filament composed of the
giant protein titin (also known as connectin). Titin molecules anchor in the Z-disc and extend …

Congestive heart failure (CHF) can result from various disease states with inadequate
cardiac output. CHF due to dilated cardiomyopathy (DCM) is a familial disease in 20–30% of …

The 364 exon TTN gene encodes titin (TTN), the largest known protein, which plays key
structural, developmental, mechanical, and regulatory roles in cardiac and skeletal muscles …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …