Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In
animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase …

Fusicoccin is the best-studied member of a class of diterpenes sharing a 5-8-5 ring structure,
called fusicoccanes. Fusicoccin was and still is a 'tool in plant physiology', targeting the main …

Mechanical forces direct a host of cellular and tissue processes. Although much emphasis
has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless …

Human carcinomas are comprised of complex mixtures of tumor cells that are known to
compete indirectly for nutrients and growth factors. Whether tumor cells could also compete …

Entosis is a mechanism of cell death that involves neighbor cell ingestion. This process
occurs in cancers and promotes a form of cell competition, where winner cells engulf and kill …

The mechanisms that regulate the spatial sorting of nonmuscle myosins-2 (NM2) isoforms
and couple them mechanically to the plasma membrane are unclear. Here we show that the …

Metastasis is complex, involving multiple genetic, epigenetic, biochemical, and physical
changes in the cancer cell and its microenvironment. Cells with metastatic potential are often …

Myosin II is a central mechanoenzyme in a wide range of cellular morphogenic processes.
Its cellular localization is dependent not only on signal transduction pathways, but also on …

Current approaches to cancer treatment focus on targeting signal transduction pathways.
Here, we develop an alternative system for targeting cell mechanics for the discovery of …

Both Dictyostelium amoebae and mammalian cells are endowed with an elaborate actin
cytoskeleton that enables them to perform a multitude of tasks essential for survival …