Lipid nanoparticles, especially liposomes and lipid/nucleic acid complexed nanoparticles
have shown great success in the pharmaceutical industry. Their success is attributed to …

Liposomes are nano-sized lipid-based vesicles widely studied for their drug delivery
capabilities. Compared to standard carries they exhibit better properties such as improved …

We performed a systematic study of thirteen alkylamines used as ion-pairing reagents for ion-
pair reversed-phase liquid chromatography (IP RP LC) separations of oligonucleotides on a …

Marketed therapies in the pharmaceutical landscape are rapidly evolving and getting more
diverse. Small molecule medicines have dominated in the past while antibodies have grown …

Liquid chromatography-mass spectrometry has been widely implemented as a powerful tool
for providing in-depth characterization of nucleic acid therapeutic modalities, such as anti …

Lipid encapsulated messenger RNA (LNP mRNA) has garnered a significant amount of
interest from the pharmaceutical industry and general public alike. This attention has been …

Therapeutic nucleic acids are various chemically modified RNA or DNA with different
functions, which mainly play roles at the gene level. Owing to its accurately targeting at …

Lipid nanoparticles (LNPs) are increasingly employed to improve delivery efficiency and
therapeutic efficacy of nucleic acids. Various formulation parameters can affect the quality …

Lipid nanoparticles (LNPs) have shown great success as drug delivery systems, especially
for mRNA vaccines, as those developed during the Covid-19 pandemics. Lipid analysis is …

Nucleic acids are the blueprint of life. They are not only the construction plan of the single
cell or higher associations of them, but also necessary for function, communication and …