Hedgehog signaling pathway is physiologically activated during embryogenesis, especially
in lung development. It is also reactivated in many solid tumors. In lung cancer, Hedgehog …

GLI transcription factors have important roles in intracellular signaling cascade, acting as the
main mediators of the HH-GLI signaling pathway. This is one of the major developmental …

Objective Gastro-oesophageal cancers (GEC) are resistant to therapy and lead to poor
prognosis. The cancer stem cells (CSCs) and antiapoptotic pathways often confer therapy …

Purpose: Esophageal cancer is a lethal disease that is often resistant to therapy. Alterations
of YAP1 and CDK6 are frequent in esophageal cancer. Deregulation of both molecules may …

Hippo/YAP1 signaling is a major regulator of organ size, cancer stemness, and aggressive
phenotype. Thus, targeting YAP1 may provide a novel therapeutic strategy for tumors with …

Esophageal cancer (EC) is an aggressive form of cancer, including squamous cell
carcinoma (ESCC) and adenocarcinoma (EAC) as two predominant histological subtypes …

Several signaling pathways are aberrantly activated in head and neck squamous cell
carcinoma (HNSCC), including the Hedgehog-Gli (HH-GLI), WNT, EGFR, and NOTCH …

Cancer stem cells (CSCs) in esophageal cancer have a key role in tumor initiation,
progression and therapy resistance. Novel therapeutic strategies to target CSCs are being …

Esophageal squamous cell carcinoma (ESCC) is one of the most intractable challenges
among human diseases with poor prognosis and shortness of effective therapeutic options …

Neoadjuvant chemoradiotherapy followed by surgery has been established as the standard
treatment for locally advanced esophageal cancer. For patients with complete regression …