Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …

Sensors are devices that respond to physical or chemical stimuli and produce detectable
signals. 1r4 They are a critical extension of human perception of the world in many aspects …

Genetically encoded sensors are powerful tools for imaging intracellular metabolites and
signaling molecules. However, developing sensors is challenging because they require …

Aptamers are single-stranded nucleic acid molecules that possess properties comparable to
those of protein monoclonal antibodies, and thus are clear alternatives to long established …

Bacteria can sense their environment, distinguish between cell types, and deliver proteins to
eukaryotic cells. Here, we engineer the interaction between bacteria and cancer cells to …

RNA molecules play important and diverse regulatory roles in the cell by virtue of their
interaction with other nucleic acids, proteins and small molecules. Inspired by this natural …

Recent studies have demonstrated the importance of noncoding RNA elements in regulating
gene expression networks,. We describe the design of a class of small trans-acting RNAs …

RNA molecules play diverse functional roles in natural biological systems. There has been
growing interest in designing synthetic RNA counterparts for programming biological …

The development of biomolecular devices that interface with biological systems to reveal
new insights and produce novel functions is one of the defining goals of synthetic biology …

Riboswitches are genetic control elements that regulate gene expression in a small
molecule-dependent way. We developed a two-stage strategy of in vitro selection followed …