The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …

Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a
selectively permeable barrier that supports nutrient absorption and waste secretion while …

Claudin family tight junction proteins form charge-and size-selective paracellular channels
that regulate epithelial barrier function. In the gastrointestinal tract, barrier heterogeneity is …

Nowadays, a large population around the world, especially the elderly, suffers from
neurological inflammatory and degenerative disorders/diseases. Current drug delivery …

The treatment of glioblastoma has limited clinical progress over the past decade, partly due
to the lack of effective drug delivery strategies across the blood-brain-tumor barrier …

The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

The homeostasis of the central nervous system (CNS) is ensured by the endothelial,
epithelial, mesothelial and glial brain barriers, which strictly control the passage of …

The paracellular passage of ions and small molecules across epithelia is controlled by tight
junctions, complex meshworks of claudin polymers that form tight seals between …

Recent evidence suggests that blood–brain barrier (BBB) recovery and reestablishment of
BBB impermeability after stroke is incomplete. This could influence stroke recovery, increase …