Personalized medicine: motivation, challenges, and progress

LH Goetz, NJ Schork - Fertility and sterility, 2018 - Elsevier
There is a great deal of hype surrounding the concept of personalized medicine.
Personalized medicine is rooted in the belief that since individuals possess nuanced and …

New frontiers in translational control of the cancer genome

ML Truitt, D Ruggero - Nature Reviews Cancer, 2016 - nature.com
The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

Gynecologic cancers and non-coding RNAs: epigenetic regulators with emerging roles

ZS Razavi, V Tajiknia, S Majidi, M Ghandali… - Critical reviews in …, 2021 - Elsevier
Gynecologic cancers involve the female genital organs, such as the vulva, vagina, cervix,
endometrium, ovaries, and fallopian tubes. The occurrence and frequency of gynecologic …

[HTML][HTML] CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence

KC Kurnit, GN Kim, BM Fellman, DL Urbauer, GB Mills… - Modern Pathology, 2017 - Elsevier
Although the majority of low grade, early stage endometrial cancer patients will have good
survival outcomes with surgery alone, those patients who do recur tend to do poorly. Optimal …

Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating …

IK Sundar, D Li, I Rahman - Journal of extracellular vesicles, 2019 - Taylor & Francis
Extracellular vesicles (EVs) play a vital role in normal lung physiology to maintain
homeostasis in the airways via intercellular communication. EVs include exosomes and …

Non-coding RNAs targeting notch signaling pathway in cancer: From proliferation to cancer therapy resistance

M Hashemi, S Hasani, S Hajimazdarany… - International Journal of …, 2022 - Elsevier
Cancer is a challenging to treat disease with a high mortality rate worldwide, nevertheless
advances in science has led to a decrease in the number of death cases caused by cancer …

[HTML][HTML] Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways

B Yang, B Xu, H Zhao, YB Wang… - Molecular …, 2018 - spandidos-publications.com
Cardiovascular diseases are common diseases in Sweden as in most countries. In 2016,
25,700 persons suffered from coronary heart disease (CHD) and 25% of these died within …

[HTML][HTML] Cancer driver gene and non-coding RNA alterations as biomarkers of brain metastasis in lung cancer: a review of the literature

M Karimpour, R Ravanbakhsh, M Maydanchi… - Biomedicine & …, 2021 - Elsevier
Brain metastasis (BM) is the most common event in patients with lung cancer. Despite
multimodal treatments and advances in systemic therapies, development of BM remains one …

Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2'-O-methylation modification of Bim

H Bao, X Chen, X Liu, W Wu, Q Li, J Xian, Y Zhao… - Cell Death …, 2022 - nature.com
The small nucleolar RNA (snoRNA) is a type of small non-coding RNA widely distributed in
the nucleoli of eukaryotic cells, promoting cancer development. The aim of this study was to …

Novel evidence for oncogenic piRNA‐823 as a promising prognostic biomarker and a potential therapeutic target in colorectal cancer

J Feng, M Yang, Q Wei, F Song, Y Zhang… - Journal of Cellular …, 2020 - Wiley Online Library
Abstract piRNA‐823 as a member of the piRNA family is reported to promote tumour cell
proliferation in multiple myeloma and hepatocellular cancer. However, few studies on the …