Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Histone-modifying enzymes are implicated in the control of diverse DNA-templated
processes including gene expression. Here, we outline historical and current thinking …

Polycomb group proteins (PcGs) maintain transcriptional repression to preserve cellular
identity in two distinct repressive complexes, PRC1 and PRC2, that modify histones by …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

The Polycomb repressive system is an essential chromatin-based regulator of gene
expression. Despite being extensively studied, how the Polycomb system selects its target …

Histone posttranslational modifications are key regulators of chromatin-associated
processes including gene expression, DNA replication and DNA repair. Monoubiquitinated …

Abstract Polycomb Group (PcG) proteins organize chromatin at multiple scales to regulate
gene expression. A conserved Sterile Alpha Motif (SAM) in the Polycomb Repressive …

The Polycomb repressive system plays a fundamental role in controlling gene expression
during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 …

The Polycomb repressive complexes PRC1, PRC2, and PR-DUB repress target genes by
modifying their chromatin. In Drosophila, PRC1 compacts chromatin and monoubiquitinates …

Stable propagation of epigenetic information is important for maintaining cell identity in
multicellular organisms. However, it remains largely unknown how mono-ubiquitinated …