Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …

T-regulatory cells (Tregs) represent a unique subpopulation of helper T-cells by maintaining
immune equilibrium using various mechanisms. The role of T-cell receptors (TCR) in …

Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated
transformation to generate a large pool of bioactive molecules. Although bile acids are …

Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …

A successful pregnancy requires a fine-tuned and highly regulated balance between
immune activation and embryonic antigen tolerance. Since the fetus is semi-allogeneic, the …

Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …

In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

At implantation, the embryo expresses paternally derived alloantigens and evokes
inflammation that can threaten reproductive success. To ensure a robust placenta and …

Developing general principles of host–microorganism interactions necessitates a robust
understanding of the eco-evolutionary processes that structure microbiota. Phylosymbiosis …