DEG 15, an update of the Database of Essential Genes that includes built-in analysis tools
Essential genes refer to genes that are required by an organism to survive under specific
conditions. Studies of the minimal-gene-set for bacteria have elucidated fundamental …
conditions. Studies of the minimal-gene-set for bacteria have elucidated fundamental …
[HTML][HTML] Two-Component Systems in Francisella Species
Bacteria alter gene expression in response to changes in their environment through various
mechanisms that include signal transduction systems. These signal transduction systems …
mechanisms that include signal transduction systems. These signal transduction systems …
Shedding light on bacteria–host interactions with the aid of TnSeq approaches
M Torres, S Paszti, L Eberl - Mbio, 2024 - Am Soc Microbiol
Bacteria are highly adaptable and grow in diverse niches, where they often interact with
eukaryotic organisms. These interactions with different hosts span the entire spectrum from …
eukaryotic organisms. These interactions with different hosts span the entire spectrum from …
[HTML][HTML] Evolution of Antibiotic Resistance in Surrogates of Francisella tularensis (LVS and Francisella novicida): Effects on Biofilm Formation and Fitness
FV Biot, BA Bachert, KD Mlynek, RG Toothman… - Frontiers in …, 2020 - frontiersin.org
Francisella tularensis, the causative agent of tularemia, is capable of causing disease in a
multitude of mammals and remains a formidable human pathogen due to a high morbidity …
multitude of mammals and remains a formidable human pathogen due to a high morbidity …
The Arabinose 5-Phosphate Isomerase KdsD Is Required for Virulence in Burkholderia pseudomallei
CH Jenkins, AE Scott, PA O'Neill, IH Norville… - Journal of …, 2023 - Am Soc Microbiol
Burkholderia pseudomallei is the causative agent of melioidosis, which is endemic primarily
in Southeast Asia and northern Australia but is increasingly being seen in other tropical and …
in Southeast Asia and northern Australia but is increasingly being seen in other tropical and …
[HTML][HTML] Tn-Seq reveals hidden complexity in the utilization of host-derived glutathione in Francisella tularensis
KM Ramsey, HE Ledvina, TM Tresko… - PLoS …, 2020 - journals.plos.org
Host-derived glutathione (GSH) is an essential source of cysteine for the intracellular
pathogen Francisella tularensis. In a comprehensive transposon insertion sequencing …
pathogen Francisella tularensis. In a comprehensive transposon insertion sequencing …
The biosynthetic pathway of ubiquinone contributes to pathogenicity of Francisella novicida
K Kazemzadeh, M Hajj Chehade, G Hourdoir… - Journal of …, 2021 - Am Soc Microbiol
Francisella tularensis is the causative agent of tularemia. Because of its extreme infectivity
and high mortality rate, this pathogen was classified as a biothreat agent. Francisella spp …
and high mortality rate, this pathogen was classified as a biothreat agent. Francisella spp …
[HTML][HTML] Fragment-based target screening as an empirical approach to prioritising targets: a case study on antibacterials
P Canning, K Birchall, CA Kettleborough, A Merritt… - Drug Discovery …, 2020 - Elsevier
Here, we describe a novel workflow combining informatic and experimental approaches to
enable evidence-based prioritising of targets from large sets in parallel. High-throughput …
enable evidence-based prioritising of targets from large sets in parallel. High-throughput …
[HTML][HTML] Novel method to recover Salmonella enterica cells for Tn-Seq approaches from lettuce leaves and agricultural environments using combination of sonication …
M Han, J Schierstaedt, Y Duan, J Trotereau… - Journal of …, 2023 - Elsevier
Salmonella enterica in agricultural environments has become an important concern, due to
its potential transmission to humans and the associated public health risks. To identify genes …
its potential transmission to humans and the associated public health risks. To identify genes …
Vector-borne diseases and tourism in Iran: current issues and recommendations
P Soltan-Alinejad, A Soltani - Travel Medicine and Infectious Disease, 2021 - Elsevier
Iran is one of the largest countries in the Middle East with lots of historical and natural
attractions. This country has always been considered to be one of the most important tourist …
attractions. This country has always been considered to be one of the most important tourist …