Essential genes refer to genes that are required by an organism to survive under specific
conditions. Studies of the minimal-gene-set for bacteria have elucidated fundamental …

Bacteria alter gene expression in response to changes in their environment through various
mechanisms that include signal transduction systems. These signal transduction systems …

Bacteria are highly adaptable and grow in diverse niches, where they often interact with
eukaryotic organisms. These interactions with different hosts span the entire spectrum from …

Francisella tularensis, the causative agent of tularemia, is capable of causing disease in a
multitude of mammals and remains a formidable human pathogen due to a high morbidity …

Burkholderia pseudomallei is the causative agent of melioidosis, which is endemic primarily
in Southeast Asia and northern Australia but is increasingly being seen in other tropical and …

Host-derived glutathione (GSH) is an essential source of cysteine for the intracellular
pathogen Francisella tularensis. In a comprehensive transposon insertion sequencing …

Francisella tularensis is the causative agent of tularemia. Because of its extreme infectivity
and high mortality rate, this pathogen was classified as a biothreat agent. Francisella spp …

Here, we describe a novel workflow combining informatic and experimental approaches to
enable evidence-based prioritising of targets from large sets in parallel. High-throughput …

Salmonella enterica in agricultural environments has become an important concern, due to
its potential transmission to humans and the associated public health risks. To identify genes …

Iran is one of the largest countries in the Middle East with lots of historical and natural
attractions. This country has always been considered to be one of the most important tourist …