Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

Background Historically, the receipt of prescription opioids has differed among racial groups
in the United States. Research has not sufficiently explored the contribution of individual …

This paper documents a marked increase in the all-cause mortality of middle-aged white
non-Hispanic men and women in the United States between 1999 and 2013. This change …

Background: Current treatments for chronic pain have limited effectiveness and commonly
known side effects. Given the prevalence and burden of intractable pain, additional …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …

Objective: We aimed to identify opioid prescribing practices across surgical specialties and
institutions. Background: In an effort to minimize the contribution of prescription narcotics to …

Pain which persists after healing is expected to have taken place, or which exists in the
absence of tissue damage, is termed chronic pain. By definition chronic pain cannot be …

Medical pain management is in crisis; from the pervasiveness of pain to inadequate pain
treatment, from the escalation of prescription opioids to an epidemic in addiction, diversion …

Importance Long-acting opioids increase the risk of unintentional overdose deaths but also
may increase mortality from cardiorespiratory and other causes. Objective To compare all …