Self-maintaining resident macrophages populate all mammalian organs. In addition to their
role as immune sentinels, macrophages perform day-to-day functions essential to tissue …

Alveolar bone is a unique osseous tissue due to the proximity of dental plaque biofilms.
Periodontal health and homeostasis are mediated by a balanced host immune response to …

Intestinal resident macrophages are at the front line of host defence at the mucosal barrier
within the gastrointestinal tract and have long been known to play a crucial role in the …

The postnatal interaction between microbiota and the immune system establishes lifelong
homeostasis at mucosal epithelial barriers, however, the barrier-specific physiological …

Extensive research in humans and animal models has begun to unravel the complex
mechanisms that drive the immunopathogenesis of periodontitis. Neutrophils mount an early …

The transforming growth factor-beta (TGF-β) signaling pathway is the predominant cytokine
signaling pathway in the development and progression of hepatocellular carcinoma (HCC) …

Immune therapeutic exosomes, derived exogenously from dendritic cells (DCs), the
'directors' of the immune response, are receiving favorable safety and tolerance profiles in …

In the present study, we investigated a novel signaling target in diabetic cardiomyopathy
where inflammation induces caspase-1-dependent cell death, pyroptosis, involving Nek7 …

Macrophages are the first immune cells in the developing embryo and have a central role in
organ development, homeostasis, immunity and repair. Over the last century, our …

Langerhans cells (LCs) are distinct among phagocytes, functioning both as embryo-derived,
tissue-resident macrophages in skin innervation and repair and as migrating professional …