Endometriosis, a disease of the macrophage

A Capobianco, P Rovere-Querini - Frontiers in immunology, 2013 - frontiersin.org
Endometriosis, a common cause of pelvic pain and female infertility, depends on the growth
of vascularized endometrial tissue at ectopic sites. Endometrial fragments reach the …

β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism

Y Ginzburg, S Rivella - Blood, The Journal of the American …, 2011 - ashpublications.org
Abstract β-thalassemia is a disease characterized by anemia and is associated with
ineffective erythropoiesis and iron dysregulation resulting in iron overload. The peptide …

Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation

P Haunhorst, EM Hanschmann… - Molecular biology of …, 2013 - Am Soc Cell Biol
The mechanisms by which eukaryotic cells handle and distribute the essential micronutrient
iron within the cytosol and other cellular compartments are only beginning to emerge. The …

[HTML][HTML] Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells

G Holmgren, J Synnergren, Y Bogestål, C Améen… - Toxicology, 2015 - Elsevier
Doxorubicin is a chemotherapeutic agent indicated for the treatment of a variety of cancer
types, including leukaemia, lymphomas, and many solid tumours. The use of doxorubicin is …

Coordinate expression of heme and globin is essential for effective erythropoiesis

RT Doty, SR Phelps, C Shadle… - The Journal of …, 2015 - Am Soc Clin Investig
Erythropoiesis requires rapid and extensive hemoglobin production. Heme activates globin
transcription and translation; therefore, heme synthesis must precede globin synthesis. As …

Chia seeds and coenzyme Q10 alleviate iron overload induced hepatorenal toxicity in mice via iron chelation and oxidative stress modulation

SA Sadek, M Marzouk, HRH Mohamed… - Scientific Reports, 2023 - nature.com
Iron overload (IOL) can cause hepatorenal damage due to iron-mediated oxidative and
mitochondrial damage. Remarkably, combining a natural iron chelator with an antioxidant …

Iron regulation by molidustat, a daily oral hypoxia-inducible factor prolyl hydroxylase inhibitor, in patients with chronic kidney disease

T Akizawa, IC Macdougall, JS Berns, H Yamamoto… - Nephron, 2019 - karger.com
Abstract Background/Aims: The current treatment for anemia associated with chronic kidney
disease (CKD) includes the administration of erythropoiesis stimulating agents (ESAs) …

Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: implications for visual manifestations of Parkinson's disease

S Baksi, AK Tripathi, N Singh - Free Radical Biology and Medicine, 2016 - Elsevier
Aggregation of α-synuclein (α-syn) in neurons of the substantia nigra is diagnostic of
Parkinson's disease (PD), a neuro-motor disorder with prominent visual symptoms. Here, we …

The role of eryptosis in the pathogenesis of renal anemia: insights from basic research and mathematical modeling

GF Dias, N Grobe, S Rogg, DJ Jörg… - Frontiers in Cell and …, 2020 - frontiersin.org
Red blood cells (RBC) are the most abundant cells in the blood. Despite powerful defense
systems against chemical and mechanical stressors, their life span is limited to about 120 …

Inherited disorders of iron metabolism

C Camaschella, E Poggiali - Current opinion in pediatrics, 2011 - journals.lww.com
Inherited disorders of iron metabolism : Current Opinion in Pediatrics Inherited disorders of iron
metabolism : Current Opinion in Pediatrics Log in or Register Subscribe to journalSubscribe Get …