Mechanisms underlying spindle assembly and robustness
The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …
Following more than a century of study, many components and pathways contributing to …
Thirty years of search and capture: The complex simplicity of mitotic spindle assembly
R Heald, A Khodjakov - Journal of Cell Biology, 2015 - rupress.org
Cell division is enacted by a microtubule-based, self-assembling macromolecular machine
known as the mitotic spindle. In 1986, Kirschner and Mitchison proposed that by undergoing …
known as the mitotic spindle. In 1986, Kirschner and Mitchison proposed that by undergoing …
Regulation of kinetochore–microtubule attachments through homeostatic control during mitosis
KM Godek, L Kabeche, DA Compton - Nature Reviews Molecular Cell …, 2015 - nature.com
Faithful chromosome segregation during mitosis is essential for genome integrity and is
mediated by the bi-oriented attachment of replicated chromosomes to spindle microtubules …
mediated by the bi-oriented attachment of replicated chromosomes to spindle microtubules …
Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis
Faithful chromosome segregation depends on the ability of sister kinetochores to attach to
spindle microtubules. The outer layer of kinetochores transiently expands in early mitosis to …
spindle microtubules. The outer layer of kinetochores transiently expands in early mitosis to …
Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces
Accurate chromosome segregation during cell division in metazoans relies on proper
chromosome congression at the equator. Chromosome congression is achieved after bi …
chromosome congression at the equator. Chromosome congression is achieved after bi …
Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins
Y Steblyanko, G Rajendraprasad, M Osswald… - The EMBO …, 2020 - embopress.org
Mitotic spindle microtubules (MT s) undergo continuous poleward flux, whose driving force
and function in humans remain unclear. Here, we combined loss‐of‐function screenings …
and function in humans remain unclear. Here, we combined loss‐of‐function screenings …
Structure of the Ndc80 complex and its interactions at the yeast kinetochore–microtubule interface
JA Zahm, S Jenni, SC Harrison - Open biology, 2023 - royalsocietypublishing.org
The conserved Ndc80 kinetochore complex, Ndc80c, is the principal link between mitotic
spindle microtubules and centromere-associated proteins. We used AlphaFold 2 (AF2) to …
spindle microtubules and centromere-associated proteins. We used AlphaFold 2 (AF2) to …
[HTML][HTML] Mislocalization of centromeric histone H3 variant CENP-A contributes to chromosomal instability (CIN) in human cells
Chromosomal instability (CIN) is a hallmark of many cancers and a major contributor to
tumorigenesis. Centromere and kinetochore associated proteins such as the evolutionarily …
tumorigenesis. Centromere and kinetochore associated proteins such as the evolutionarily …
[HTML][HTML] Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression
Error-free chromosome segregation in mitosis and meiosis relies on the assembly of a
microtubule-based spindle that interacts with kinetochores to guide chromosomes to the cell …
microtubule-based spindle that interacts with kinetochores to guide chromosomes to the cell …