The cell biology of synapse formation

TC Südhof - Journal of Cell Biology, 2021 - rupress.org
In a neural circuit, synapses transfer information rapidly between neurons and transform this
information during transfer. The diverse computational properties of synapses are shaped by …

Towards an understanding of synapse formation

TC Südhof - Neuron, 2018 - cell.com
Synapses are intercellular junctions specialized for fast, point-to-point information transfer
from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal …

Synaptic neurexin complexes: a molecular code for the logic of neural circuits

TC Südhof - Cell, 2017 - cell.com
Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …

Spine dynamics in the brain, mental disorders and artificial neural networks

H Kasai, NE Ziv, H Okazaki, S Yagishita… - Nature Reviews …, 2021 - nature.com
In the brain, most synapses are formed on minute protrusions known as dendritic spines.
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …

Neurexins: molecular codes for shaping neuronal synapses

AM Gomez, L Traunmüller, P Scheiffele - Nature Reviews …, 2021 - nature.com
The function of neuronal circuits relies on the properties of individual neuronal cells and
their synapses. We propose that a substantial degree of synapse formation and function is …

Fluid biomarkers for synaptic dysfunction and loss

E Camporesi, J Nilsson, A Brinkmalm… - Biomarker …, 2020 - journals.sagepub.com
Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …

Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice

C Shang, Z Chen, A Liu, Y Li, J Zhang, B Qu… - Nature …, 2018 - nature.com
Animals respond to environmental threats, eg looming visual stimuli, with innate defensive
behaviors such as escape and freezing. The key neural circuits that participate in the …

A common thalamic hub for general and defensive arousal control

Y Wang, L You, KM Tan, M Li, J Zou, Z Zhao, W Hu, T Li… - Neuron, 2023 - cell.com
The expression of defensive responses to alerting sensory cues requires both general
arousal and a specific arousal state associated with defensive emotions. However, it …

Binary and analog variation of synapses between cortical pyramidal neurons

S Dorkenwald, NL Turner, T Macrina, K Lee, R Lu… - Elife, 2022 - elifesciences.org
Learning from experience depends at least in part on changes in neuronal connections. We
present the largest map of connectivity to date between cortical neurons of a defined type …

Functional neuronal circuits emerge in the absence of developmental activity

DL Barabási, GFP Schuhknecht, F Engert - Nature Communications, 2024 - nature.com
The complex neuronal circuitry of the brain develops from limited information contained in
the genome. After the genetic code instructs the birth of neurons, the emergence of brain …