Unraveling the complexities of the HDL lipidome1
A Kontush, M Lhomme, MJ Chapman - Journal of lipid research, 2013 - ASBMB
Plasma high density lipoproteins (HDL) are small, dense, protein-rich particles compared
with other lipoprotein classes; roughly half of total HDL mass is accounted for by lipid …
with other lipoprotein classes; roughly half of total HDL mass is accounted for by lipid …
Targeting inflammation in metabolic syndrome
FK Welty, A Alfaddagh, TK Elajami - Translational research, 2016 - Elsevier
The metabolic syndrome (MetS) is comprised of a cluster of closely related risk factors,
including visceral adiposity, insulin resistance, hypertension, high triglyceride, and low high …
including visceral adiposity, insulin resistance, hypertension, high triglyceride, and low high …
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
JR Nofer, M Van Der Giet, M Tölle… - The Journal of …, 2004 - Am Soc Clin Investig
HDL is a major atheroprotective factor, but the mechanisms underlying this effect are still
obscure. HDL binding to scavenger receptor-BI has been shown to activate eNOS, although …
obscure. HDL binding to scavenger receptor-BI has been shown to activate eNOS, although …
Endothelial and antithrombotic actions of HDL
C Mineo, H Deguchi, JH Griffin, PW Shaul - Circulation research, 2006 - Am Heart Assoc
It is well recognized that high-density lipoprotein (HDL)-cholesterol is antiatherogenic and
serves a role in mediating cholesterol efflux from cells. However, HDL has multiple …
serves a role in mediating cholesterol efflux from cells. However, HDL has multiple …
HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis
AR Tall, L Yvan-Charvet, N Terasaka, T Pagler… - Cell metabolism, 2008 - cell.com
High-density lipoprotein (HDL) has been identified as a potential target in the treatment of
atherosclerotic vascular disease. The failure of torcetrapib, an inhibitor of cholesteryl ester …
atherosclerotic vascular disease. The failure of torcetrapib, an inhibitor of cholesteryl ester …
[HTML][HTML] Role of cholesterol in the development and progression of breast cancer
G Llaverias, C Danilo, I Mercier, K Daumer… - The American journal of …, 2011 - Elsevier
Diet and obesity are important risk factors for cancer development. Many studies have
suggested an important role for several dietary nutrients in the progression and …
suggested an important role for several dietary nutrients in the progression and …
Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL
The concentration, composition, shape, and size of plasma high-density lipoprotein (HDL)
are determined by numerous proteins that influence its biogenesis, remodeling, and …
are determined by numerous proteins that influence its biogenesis, remodeling, and …
HDL as a target in the treatment of atherosclerotic cardiovascular disease
P Linsel-Nitschke, AR Tall - Nature reviews Drug discovery, 2005 - nature.com
Lipid abnormalities are among the key risk factors for cardiovascular disease. Indeed, lipid-
modifying drugs—in particular, the statins, which primarily lower plasma levels of low …
modifying drugs—in particular, the statins, which primarily lower plasma levels of low …
Cholesterol efflux pathways and other potential mechanisms involved in the athero‐protective effect of high density lipoproteins
AR Tall - Journal of internal medicine, 2008 - Wiley Online Library
Plasma high density lipoprotein (HDL) levels bear a strong independent inverse relationship
with atherosclerotic cardiovascular disease. Although HDL has anti‐oxidant, anti …
with atherosclerotic cardiovascular disease. Although HDL has anti‐oxidant, anti …
Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities
SR Thomas, PK Witting… - Antioxidants & redox …, 2008 - liebertpub.com
The endothelium is essential for the maintenance of vascular homeostasis. Central to this
role is the production of endothelium-derived nitric oxide (EDNO), synthesized by the …
role is the production of endothelium-derived nitric oxide (EDNO), synthesized by the …