Novel applications of micro total analysis systems (μTAS) are addressing fundamental
biological questions, creating new biomedical reagents, and developing innovative cell and …

For unicellular organisms, the decision to enter the cell cycle can be viewed most
fundamentally as a metabolic problem. A cell must assess its nutritional and metabolic status …

Eukaryotic cell division is known to be controlled by the cyclin/cyclin dependent kinase
(CDK) machinery. However, eukaryotes have evolved prior to CDKs, and cells can divide in …

Exposure of cells to visible light in nature or in fluorescence microscopy often is considered
to be relatively innocuous. However, using the yeast respiratory oscillation (YRO) as a …

Under continuous, glucose-limited conditions, budding yeast exhibit robust metabolic cycles
associated with major oscillations of gene expression. How such fluctuations are linked to …

The recently observed circadian oscillations of the intestinal microbiota underscore the
profound nature of the human–microbiome relationship and its importance for health …

While we have a solid understanding of the cell biological and biochemical control aspects
of the eukaryotic cell growth and division process, much less is known about the metabolic …

In the past decade, major advances have occurred in the understanding of mammalian stem
cell biology, but roadblocks (including gaps in our fundamental understanding) remain in …

Adaptive survival requires the coordination of nutrient availability with expenditure of cellular
resources. For example, in nutrient-limited environments, 50% of all S. cerevisiae genes …

The circadian clock is a cellular timekeeping mechanism that helps organisms from bacteria
to humans to organize their behaviour and physiology around the solar cycle. Current …