Structural insights into the signalling mechanisms of two-component systems

F Jacob-Dubuisson, A Mechaly, JM Betton… - Nature Reviews …, 2018 - nature.com
Two-component systems reprogramme diverse aspects of microbial physiology in response
to environmental cues. Canonical systems are composed of a transmembrane sensor …

Blue-light receptors for optogenetics

A Losi, KH Gardner, A Möglich - Chemical reviews, 2018 - ACS Publications
Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

Two-component sensing and regulation: how do histidine kinases talk with response regulators at the molecular level?

A Buschiazzo, F Trajtenberg - Annual review of microbiology, 2019 - annualreviews.org
Perceiving environmental and internal information and reacting in adaptive ways are
essential attributes of living organisms. Two-component systems are relevant protein …

Individual and shared digital repertoires–older adults managing digital services

R Hänninen, L Pajula, V Korpela… - … Communication & Society, 2023 - Taylor & Francis
The rise of public and other non-recreational digital services is based on the idea of catering
to the daily needs of the citizens cost-efficiently and with ease. Previous research has …

[HTML][HTML] Light-oxygen-voltage (LOV)-sensing domains: activation mechanism and optogenetic stimulation

A Flores-Ibarra, RNA Maia, B Olasz, JR Church… - Journal of molecular …, 2024 - Elsevier
The light-oxygen-voltage (LOV) domains of phototropins emerged as essential constituents
of light-sensitive proteins, helping initiate blue light-triggered responses. Moreover, these …

Temperature-jump solution X-ray scattering reveals distinct motions in a dynamic enzyme

MC Thompson, BA Barad, AM Wolff, H Sun Cho… - Nature …, 2019 - nature.com
Correlated motions of proteins are critical to function, but these features are difficult to
resolve using traditional structure determination techniques. Time-resolved X-ray methods …

Comparative analysis of two paradigm bacteriophytochromes reveals opposite functionalities in two-component signaling

E Multamäki, R Nanekar, D Morozov… - Nature …, 2021 - nature.com
Bacterial phytochrome photoreceptors usually belong to two-component signaling systems
which transmit environmental stimuli to a response regulator through a histidine kinase …

A blue light receptor that mediates RNA binding and translational regulation

AM Weber, J Kaiser, T Ziegler, S Pilsl, C Renzl… - Nature chemical …, 2019 - nature.com
Sensory photoreceptor proteins underpin light-dependent adaptations in nature and enable
the optogenetic control of organismal behavior and physiology. We identified the bacterial …

Signal transduction in photoreceptor histidine kinases

A Möglich - Protein science, 2019 - Wiley Online Library
Two‐component systems (TCS) constitute the predominant means by which prokaryotes
read out and adapt to their environment. Canonical TCSs comprise a sensor histidine kinase …

A guide to time‐resolved structural analysis of light‐activated proteins

H Poddar, DJ Heyes, G Schirò, M Weik… - The FEBS …, 2022 - Wiley Online Library
Dynamical changes in protein structures are essential for protein function and occur over
femtoseconds to seconds timescales. X‐ray free electron lasers have facilitated …