According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

Chemical tools have accelerated progress in glycoscience, reducing experimental barriers
to studying protein glycosylation, the most widespread and complex form of posttranslational …

Post-translational modifications modulate the activity of most eukaryote proteins. Analysis of
these modifications presents formidable challenges but their determination generates …

Peptide sequence analysis using a combination of gas-phase ion/ion chemistry and tandem
mass spectrometry (MS/MS) is demonstrated. Singly charged anthracene anions transfer an …

Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale
proteomics. In this review, we dissect the overall framework of the MS experiment into its key …

Mass spectrometry (MS) has progressed to become a powerful analytical tool for both
quantitative and qualitative applications. The first mass spectrometer was constructed in …

Imaging mass spectrometry combines the chemical specificity and parallel detection of mass
spectrometry with microscopic imaging capabilities. The ability to simultaneously obtain …

Since poly-ADP ribose was discovered over 40 years ago, there has been significant
progress in research into the biology of mono-and poly-ADP-ribosylation reactions. During …

For proteins of< 20 kDa, this new radical site dissociation method cleaves different and
many more backbone bonds than the conventional MS/MS methods (eg, collisionally …