One quarter of the global population is estimated to have nonalcoholic fatty liver disease
(NAFLD). The incidence of nonalcoholic steatohepatitis (NASH) is projected to increase by …

Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and
morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the …

Ferroptosis is a nonapoptotic, iron-dependent form of cell death that can be activated in
cancer cells by natural stimuli and synthetic agents. Three essential hallmarks define …

Acetyl-coenzyme A (acetyl-CoA) is a central metabolic intermediate. The abundance of
acetyl-CoA in distinct subcellular compartments reflects the general energetic state of the …

The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to
produce sterols and isoprenoids that are integral to tumour growth and progression. In …

The YAP and TAZ mediators of the Hippo pathway (hereafter called YAP/TAZ) promote
tissue proliferation and organ growth. However, how their biological properties intersect with …

Background A reduction in the availability of cholesterol may limit the cellular proliferation
required for cancer growth and metastasis. We tested the hypothesis that statin use begun …

Due to the aging of the populations of developed countries and a common occurrence of risk
factors, it is increasingly probable that a patient may have both cancer and cardiovascular …

A hallmark of cancer cells includes a metabolic reprograming that provides energy, the
essential building blocks, and signaling required to maintain survival, rapid growth …

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is a leading cause of cancer-
related mortality worldwide. Several studies have shown that statins could have …