Abstract The TGF beta-1,-2 and-3 isoforms are transcribed from different genes but bind to
the same receptors and signal through the same canonical and non-canonical signal …

Myofibroblasts are alpha-smooth muscle actin (SMA)+ cells that have a critical role in the
corneal stromal response to infections, injuries, and surgeries, and which produce corneal …

Losartan is an angiotensin II receptor blocker (ARB) that impedes transforming growth factor
(TGF) beta signaling by inhibiting activation of signal transduction molecule extracellular …

Excessive connective tissue accumulation, a hallmark of hypertrophic scaring, results in
progressive deterioration of the structure and function of organs. It can also be seen during …

Purpose: Interleukin (IL)-1α/IL-1β and transforming growth factor (TGF) β1/TGFβ2 have both
been promoted as “master regulators” of the corneal wound healing response due to the …

Purpose: To highlight the cellular, matrix, and hydration changes associated with opacity
that occurs in the corneal stroma after injury. Methods: Review of the literature. Results: The …

Purpose To review the functions of corneal fibroblasts in wound healing. Methods Literature
review. Results Corneal fibroblasts arise in the corneal stroma after anterior, posterior or …

Mesenchymal cells (keratocytes, corneal fibroblasts, and myofibroblasts), as well as
mesenchymal progenitor bone marrow-derived fibrocytes, are the major cellular contributors …

Every organ develops fibrosis that compromises functions in response to infections, injuries,
or diseases. The cornea is a relatively simple, avascular organ that offers an exceptional …

Purpose To understand which cell types, either alone or in combination, contribute to the
assembly of the epithelial basement membrane (BM) during corneal wound healing …