TGF Beta− 1,− 2 and− 3 in the Modulation of Fibrosis in the Cornea and Other Organs
SE Wilson - Experimental eye research, 2021 - Elsevier
Abstract The TGF beta-1,-2 and-3 isoforms are transcribed from different genes but bind to
the same receptors and signal through the same canonical and non-canonical signal …
the same receptors and signal through the same canonical and non-canonical signal …
Corneal myofibroblasts and fibrosis
SE Wilson - Experimental eye research, 2020 - Elsevier
Myofibroblasts are alpha-smooth muscle actin (SMA)+ cells that have a critical role in the
corneal stromal response to infections, injuries, and surgeries, and which produce corneal …
corneal stromal response to infections, injuries, and surgeries, and which produce corneal …
Topical losartan: practical guidance for clinical trials in the prevention and treatment of corneal scarring fibrosis and other eye diseases and disorders
SE Wilson - Journal of Ocular Pharmacology and Therapeutics, 2023 - liebertpub.com
Losartan is an angiotensin II receptor blocker (ARB) that impedes transforming growth factor
(TGF) beta signaling by inhibiting activation of signal transduction molecule extracellular …
(TGF) beta signaling by inhibiting activation of signal transduction molecule extracellular …
[HTML][HTML] Molecular changes underlying hypertrophic scarring following burns involve specific deregulations at all wound healing stages (inflammation, proliferation …
M Čoma, L Fröhlichová, L Urban, R Zajíček… - International Journal of …, 2021 - mdpi.com
Excessive connective tissue accumulation, a hallmark of hypertrophic scaring, results in
progressive deterioration of the structure and function of organs. It can also be seen during …
progressive deterioration of the structure and function of organs. It can also be seen during …
[HTML][HTML] Interleukin-1 and transforming growth factor beta: commonly opposing, but sometimes supporting, master regulators of the corneal wound healing response to …
SE Wilson - Investigative ophthalmology & visual science, 2021 - arvojournals.org
Purpose: Interleukin (IL)-1α/IL-1β and transforming growth factor (TGF) β1/TGFβ2 have both
been promoted as “master regulators” of the corneal wound healing response due to the …
been promoted as “master regulators” of the corneal wound healing response due to the …
[HTML][HTML] Corneal opacity: cell biological determinants of the transition from transparency to transient haze to scarring fibrosis, and resolution, after injury
Purpose: To highlight the cellular, matrix, and hydration changes associated with opacity
that occurs in the corneal stroma after injury. Methods: Review of the literature. Results: The …
that occurs in the corneal stroma after injury. Methods: Review of the literature. Results: The …
The corneal fibroblast: the Dr. Jekyll underappreciated overseer of the responses to stromal injury
SE Wilson - The Ocular Surface, 2023 - Elsevier
Purpose To review the functions of corneal fibroblasts in wound healing. Methods Literature
review. Results Corneal fibroblasts arise in the corneal stroma after anterior, posterior or …
review. Results Corneal fibroblasts arise in the corneal stroma after anterior, posterior or …
[HTML][HTML] The yin and yang of mesenchymal cells in the corneal stromal fibrosis response to injury: the cornea as a model of fibrosis in other organs
SE Wilson - Biomolecules, 2022 - mdpi.com
Mesenchymal cells (keratocytes, corneal fibroblasts, and myofibroblasts), as well as
mesenchymal progenitor bone marrow-derived fibrocytes, are the major cellular contributors …
mesenchymal progenitor bone marrow-derived fibrocytes, are the major cellular contributors …
[HTML][HTML] Fibrosis is a basement membrane-related disease in the cornea: injury and defective regeneration of basement membranes may underlie fibrosis in other …
SE Wilson - Cells, 2022 - mdpi.com
Every organ develops fibrosis that compromises functions in response to infections, injuries,
or diseases. The cornea is a relatively simple, avascular organ that offers an exceptional …
or diseases. The cornea is a relatively simple, avascular organ that offers an exceptional …
[HTML][HTML] Corneal epithelial basement membrane assembly is mediated by epithelial cells in coordination with corneal fibroblasts during wound healing
Purpose To understand which cell types, either alone or in combination, contribute to the
assembly of the epithelial basement membrane (BM) during corneal wound healing …
assembly of the epithelial basement membrane (BM) during corneal wound healing …