Translational opportunities in animal and human models to study alcohol use disorder
Animal and human laboratory paradigms offer invaluable approaches to study the complex
etiologies and mechanisms of alcohol use disorder (AUD). We contend that human …
etiologies and mechanisms of alcohol use disorder (AUD). We contend that human …
Evidence for incentive salience sensitization as a pathway to alcohol use disorder
The incentive salience sensitization (ISS) theory of addiction holds that addictive behavior
stems from the ability of drugs to progressively sensitize the brain circuitry that mediates …
stems from the ability of drugs to progressively sensitize the brain circuitry that mediates …
Positive and negative reinforcement are differentially associated with alcohol consumption as a function of alcohol dependence.
A multistage model of drug addiction in which individuals' motivations for use change as
they develop problems is widely accepted; however, the evidence for this model comes …
they develop problems is widely accepted; however, the evidence for this model comes …
Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone
P Bach, G Weil, E Pompili, S Hoffmann… - Addiction …, 2020 - Wiley Online Library
During the first weeks of abstinence, alcohol craving in patients may increase or “incubate.”
We hypothesize that Naltrexone (NTX) blocks this incubation effect. Here, we compared NTX …
We hypothesize that Naltrexone (NTX) blocks this incubation effect. Here, we compared NTX …
Subjective responses to alcohol in the development and maintenance of alcohol use disorder
A King, A Vena, DS Hasin, H DeWit… - American Journal of …, 2021 - Am Psychiatric Assoc
Objective: Alcohol use disorder (AUD) remains an urgent public health problem.
Longitudinal data are needed to clarify the role of acute subjective responses to alcohol in …
Longitudinal data are needed to clarify the role of acute subjective responses to alcohol in …
Naltrexone effects on subjective responses to alcohol in the human laboratory: A systematic review and meta‐analysis
Naltrexone (NTX) has been widely studied for the treatment of alcohol use disorder with
overall support for its efficacy. The mechanisms of action of naltrexone are thought to involve …
overall support for its efficacy. The mechanisms of action of naltrexone are thought to involve …
Subjective response to alcohol as a research domain criterion
Background Individual differences in the subjective experience of the pharmacological
effects of alcohol have long been implicated in the likelihood that one will drink heavily and …
effects of alcohol have long been implicated in the likelihood that one will drink heavily and …
Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies
A major hypothesis in the addiction field suggests deficits in dopamine signaling during
abstinence as a driving mechanism for the relapsing course of the disorder. Paradoxically …
abstinence as a driving mechanism for the relapsing course of the disorder. Paradoxically …
Differential effects of UPPS-P impulsivity on subjective alcohol response and craving: An experimental test of acquired preparedness.
Recent studies have extended the acquired preparedness model to experimental data,
finding that impulsivity predicts subjective alcohol response, a related yet distinct construct …
finding that impulsivity predicts subjective alcohol response, a related yet distinct construct …
[HTML][HTML] Differences in the subjective and motivational properties of alcohol across alcohol use severity: application of a novel translational human laboratory …
Abstract The Allostatic Model proposes that Alcohol Use Disorder (AUD) is associated with a
transition in the motivational structure of alcohol drinking: from positive reinforcement in …
transition in the motivational structure of alcohol drinking: from positive reinforcement in …