This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

Synchronous rhythms represent a core mechanism for sculpting temporal coordination of
neural activity in the brain-wide network. This review focuses on oscillations in the cerebral …

Dorsal root ganglion (DRG) sensory neuron subtypes defined by their in vivo properties
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …

The action potential of the squid giant axon is formed by just two voltage-dependent
conductances in the cell membrane, yet mammalian central neurons typically express more …

Light-controllable tools provide powerful means to manipulate and interrogate brain function
with relatively low invasiveness and high spatiotemporal precision. Although optogenetic …

Small-conductance Ca2+-activated K+ channels (SK channels) are widely expressed
throughout the central nervous system. These channels are activated solely by increases in …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

Abstract Analysis of the Kv3 subfamily of K+ channel subunits has lead to the discovery of a
new class of neuronal voltage-gated K+ channels characterized by positively shifted voltage …

APOE is the strongest genetic risk factor for late-onset Alzheimer's disease. ApoE
exacerbates tau-associated neurodegeneration by driving microglial activation. However …

Mutations in ion channels involved in the generation and termination of action potentials
constitute a family of molecular defects that underlie fatal cardiac arrhythmias in inherited …