Until recently, it was considered unethical or impossible to perform clinical trials of new
medicines in children. As a consequence, many medicines used for treating children are …

Purpose The aim of this review is to assess the extent of the use of off-label and/or
unlicenced drugs among hospitalised children. Methods A systematic search was made in …

Background Off-label and unlicensed (OLUL) prescribing has been prevalent in pediatric
practice. Using data from a prospective cohort study of adverse drug reactions (ADRs) …

While a large number of studies has examined the efficacy of opioid-sparing analgesics in
adult surgical populations, fewer studies are available to guide postoperative pain treatment …

Purpose To evaluate the use of off-label and unlicensed medicines in a neonatal intensive
care unit (NICU) of a teaching maternity hospital specialized in high risk pregnancy …

Aims To examine the impact of off‐label and unlicensed (OLUL) prescribing on adverse
drug reactions (ADR s) causing unplanned admissions to a paediatric hospital. Methods …

Background In the past two decades, many legislative and regulatory initiatives were taken
globally to improve drug use in children. However, children are still found to be prescribed …

Background: Given the growing use of off-label in pediatric practice, there is a growing
interest on pharmacovigilance programs monitoring the occurrence of adverse drug …

目的系统评价国内外住院儿童超说明书用药现状. 方法计算机检索PubMed, EMbase, CBM,
CNKI 和VIP 数据库, 纳入中, 英文发表的0~ 18 岁住院儿童超说明书用药研究, 以Combieg …

The use of unlicensed and off-label medicines in children is common because trials in
children have not usually been performed during the drug development process …