TRPV3 Ion Channel: from gene to Pharmacology

AP Kalinovskii, LL Utkina, YV Korolkova… - International Journal of …, 2023 - mdpi.com
Transient receptor potential vanilloid subtype 3 (TRPV3) is an ion channel with a sensory
function that is most abundantly expressed in keratinocytes and peripheral neurons. TRPV3 …

Therapeutic potential of pharmacological agents targeting TRP channels in CNS disorders

P Thapak, B Vaidya, HC Joshi, JN Singh… - Pharmacological …, 2020 - Elsevier
Central nervous system (CNS) disorders like Alzheimer's disease (AD), Parkinson disease
(PD), stroke, epilepsy, depression, and bipolar disorder have a high impact on both medical …

Hypothyroidism induces motor deficit via altered cerebellar HB-EGF/EGFR and autophagy

J Vishwakarma, K Gupta, J Mishra… - Journal of …, 2023 - joe.bioscientifica.com
Thyroid hormones (TH) are vital for brain functions, while TH deficiency, ie hypothyroidism,
induces neurological impairment in children and adults. Cerebellar neuronal apoptosis and …

Role of TRP ion channels in pruritus

P Shirolkar, SK Mishra - Neuroscience letters, 2022 - Elsevier
The transient receptor potential (TRP) channel superfamily responds to various physical,
chemical, and environmental stimuli including the detection of sensations both harmful and …

Fra‐1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury

Y Chen, Y Dong, ZL Zhang, J Han, FS Chen… - Brain …, 2023 - Wiley Online Library
Spinal cord ischemia/reperfusion injury (SCII) is a severe complication driven by apoptosis
and neuroinflammation. An increase in the expression of c‐Fos, a member of the AP‐1 …

TRPV3 endogenously expressed in murine colonic epithelial cells is inhibited by the novel TRPV3 blocker 26E01

M Bischof, S Olthoff, C Glas, O Thorn-Seshold… - Cell Calcium, 2020 - Elsevier
Abstract TRPV3 is a Ca 2+-permeable cation channel, prominently expressed by
keratinocytes where it contributes to maintaining the skin barrier, skin regeneration, and …

Therapeutic potential of transient receptor potential (TRP) channels in psychiatric disorders

V Sharma, P Sharma, TG Singh - Journal of Neural Transmission, 2024 - Springer
Psychiatric disorders such as Bipolar disorder, Anxiety, Major depressive disorder,
Schizophrenia, Attention-deficit/hyperactivity disorder, as well as neurological disorders …

Ketamine abrogates sensorimotor deficits and cytokine dysregulation in a chronic unpredictable mild stress model of depression

EE Edem, CKC Anyanwu, KE Nebo, ET Akinluyi… - …, 2022 - Springer
Major depressive disorder (MDD) is a serious mental disorder with influence across the
functional systems of the body. The pathogenesis of MDD has been known to involve the …

The neglected role of endocannabinoid actions at TRPC channels in ataxia

H Ranjbar, M Soti, M Razavinasab… - Neuroscience & …, 2022 - Elsevier
Transient receptor potential (TRP) channels are highly expressed in cells of the cerebellum
including in the dendrites and somas of Purkinje cells (PCs). Their endogenous activation …

Genetic associations of dimensional autistic phenotypes

T Eriksson, C Nakamori, K Iwamoto - bioRxiv, 2023 - biorxiv.org
Since there is a large variation in the symptoms shown by persons affected with ASD,
analyzing genetics data using a case-control design is not straightforward. To avoid the …