Free-radicals (Oxygen and Nitrogen species) are formed in mitochondria during the
oxidative phosphorylation. Their high reactivity, due to not-engaged electrons, leads to an …

Clinical manifestations typical of mitochondrial diseases are often present in various genetic
syndromes associated with intellectual disability, a condition leading to deficit in cognitive …

Mutations in the cytosine‐5 RNA methyltransferase NSun2 cause microcephaly and other
neurological abnormalities in mice and human. How post‐transcriptional methylation …

The orchestrated organization of epigenetic factors that control chromatin dynamism,
including DNA methylation, histone marks, non-coding RNAs (ncRNAs) and chromatin …

Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively
females, caused in the overwhelming majority of the cases by loss-of-function mutations in …

KDM5 family proteins are critically important transcriptional regulators whose physiological
functions in the context of a whole animal remain largely unknown. Using genome-wide …

Oxidative stress is a key contributor to the pathogenesis of stroke-reperfusion injury.
Neuroinflammatory peptides released after ischemic stroke mediate reperfusion injury …

Rett (RTT) syndrome is a severe neurological disorder that affects almost exclusively
females. Several detectable mutations in the X-linked methyl-CpG-binding protein 2 gene …

Disorders of autonomic functions are typically characterized by disturbances in multiple
organ systems. These disturbances are often comorbidities of common and rare diseases …

In the last two decades, the human sperm count linearly decreased in Western countries.
Health problems, lifestyle, pollutants, and dietary behaviours are considered as the main risk …