Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve
T cell activation and effector differentiation. They are, likewise, involved in the induction and …

The three-signal paradigm tries to capture how the innate immune system instructs adaptive
immune responses in three well-defined actions:(1) presentation of antigenic peptides in the …

Numerous analyses of large patient cohorts identified specific patterns of immune activation
associated with patient survival. We established these as the immune contexture …

Mesenchymal stromal cells (MSCs) are potent regulators of immune responses largely
through paracrine signaling. MSC secreted extracellular vesicles (MSC-EVs) are …

The gut microbiota is essential for human health and plays an important role in the
pathogenesis of several diseases. Short-chain fatty acids (SCFA), such as acetate, butyrate …

Dendritic cells (DCs) are considered as professional antigen presenting cells (APCs),
containing a variety of subsets, that can be resident in organs or migrating among the …

Treating large established tumors is challenging for dendritic cell (DC)-based
immunotherapy. DC activation with tumor cell-derived exosomes (TEXs) carrying multiple …

Tumors evade the immune system though a myriad of mechanisms. Using checkpoint
inhibitors to help reprime T cells to recognize tumor has had great success in malignancies …

Efficacy of cancer vaccines remains low and mechanistic understanding of antigen
presenting cell function in cancer may improve vaccine design and outcomes. Here, we …

Immune modulation is one of the most effective approaches in the therapy of complex
diseases, including public health emergency. However, most immune therapeutics such as …