Brain energy and oxygen metabolism: emerging role in normal function and disease
Dynamic metabolic changes occurring in neurons are critically important in directing brain
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …
Inflammation and cancer: back to Virchow?
F Balkwill, A Mantovani - The lancet, 2001 - thelancet.com
The response of the body to a cancer is not a unique mechanism but has many parallels
with inflammation and wound healing. This article reviews the links between cancer and …
with inflammation and wound healing. This article reviews the links between cancer and …
Hypoxia—a key regulatory factor in tumour growth
AL Harris - Nature reviews cancer, 2002 - nature.com
Cells undergo a variety of biological responses when placed in hypoxic conditions,
including activation of signalling pathways that regulate proliferation, angiogenesis and …
including activation of signalling pathways that regulate proliferation, angiogenesis and …
Roles of extracellular HSPs as biomarkers in immune surveillance and immune evasion
EA Taha, K Ono, T Eguchi - International Journal of Molecular Sciences, 2019 - mdpi.com
Extracellular heat shock proteins (ex-HSPs) have been found in exosomes, oncosomes,
membrane surfaces, as well as free HSP in cancer and various pathological conditions, also …
membrane surfaces, as well as free HSP in cancer and various pathological conditions, also …
Oxygen sensing by HIF hydroxylases
CJ Schofield, PJ Ratcliffe - Nature reviews Molecular cell biology, 2004 - nature.com
The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen
homeostasis in animals ranging from nematode worms to man. Recent studies have shown …
homeostasis in animals ranging from nematode worms to man. Recent studies have shown …
Hypoxia-inducible expression of tumor-associated carbonic anhydrases
The transcriptional complex hypoxia-inducible factor-1 (HIF-1) has emerged as an important
mediator of gene expression patterns in tumors, although the range of responding genes is …
mediator of gene expression patterns in tumors, although the range of responding genes is …
Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight …
In human obesity, the stroma vascular fraction (SVF) of white adipose tissue (WAT) is
enriched in macrophages. These cells may contribute to low-grade inflammation and to its …
enriched in macrophages. These cells may contribute to low-grade inflammation and to its …
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
The mechanisms responsible for recruiting monocytes from the bloodstream into solid
tumors are now well characterized. However, recent evidence has shown that these cells …
tumors are now well characterized. However, recent evidence has shown that these cells …
Role of tumor-associated macrophages in tumor progression and invasion
A Mantovani, T Schioppa, C Porta, P Allavena… - Cancer and Metastasis …, 2006 - Springer
Abstract Tumor-Associated Macrophages (TAM) represent the major inflammatory
component of the stroma of many tumors, able to affect different aspects of the neoplastic …
component of the stroma of many tumors, able to affect different aspects of the neoplastic …
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
J Ye, Z Gao, J Yin, Q He - American Journal of Physiology …, 2007 - journals.physiology.org
Chronic inflammation and reduced adiponectin are widely observed in the white adipose
tissue in obesity. However, the cause of the changes remains to be identified. In this study …
tissue in obesity. However, the cause of the changes remains to be identified. In this study …