Surface loops of trypsin-like serine proteases as determinants of function
P Goettig, H Brandstetter, V Magdolen - Biochimie, 2019 - Elsevier
Trypsin and chymotrypsin-like serine proteases from family S1 (clan PA) constitute the
largest protease group in humans and more generally in vertebrates. The prototypes …
largest protease group in humans and more generally in vertebrates. The prototypes …
Structural insights into the activation mechanisms of human HtrA serine proteases
D Zurawa-Janicka, T Wenta, M Jarzab… - Archives of biochemistry …, 2017 - Elsevier
Human HtrA1-4 proteins belong to the HtrA family of evolutionarily conserved serine
proteases and function as important modulators of many physiological processes, including …
proteases and function as important modulators of many physiological processes, including …
[HTML][HTML] Overview of human HtrA family proteases and their distinctive physiological roles and unique involvement in diseases, especially cancer and pregnancy …
Y Wang, G Nie - International Journal of Molecular Sciences, 2021 - mdpi.com
The mammalian high temperature requirement A (HtrA) proteins are a family of
evolutionarily conserved serine proteases, consisting of four homologs (HtrA1-4) that are …
evolutionarily conserved serine proteases, consisting of four homologs (HtrA1-4) that are …
[HTML][HTML] Transcriptome analysis of hypoxic lymphatic endothelial cells indicates their potential to contribute to extracellular matrix rearrangement
J Becker, S Schwoch, C Zelent, M Sitte, G Salinas… - Cells, 2021 - mdpi.com
Lymphedema (LE) affects millions of people worldwide. It is a chronic progressive disease
with massive development of fibrosclerosis when untreated. There is no pharmacological …
with massive development of fibrosclerosis when untreated. There is no pharmacological …
[HTML][HTML] Interplay between HTRA1 and classical signalling pathways in organogenesis and diseases
The high temperature requirement factor A1 (HTRA1) is a serine protease which modulates
an array of signalling pathways driving basal biological processes. HTRA1 plays a …
an array of signalling pathways driving basal biological processes. HTRA1 plays a …
[HTML][HTML] Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions
U Zarzecka, A Modrak-Wójcik, D Figaj… - Frontiers in …, 2019 - frontiersin.org
The protease high temperature requirement A from the gastric pathogen Helicobacter pylori
(HtrA Hp) belongs to the well conserved family of serine proteases. HtrA Hp is an important …
(HtrA Hp) belongs to the well conserved family of serine proteases. HtrA Hp is an important …
[HTML][HTML] Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration
The trimeric serine protease HTRA1 is a genetic risk factor associated with geographic
atrophy (GA), a currently untreatable form of age-related macular degeneration. Here, we …
atrophy (GA), a currently untreatable form of age-related macular degeneration. Here, we …
[HTML][HTML] The Scleraxis transcription factor directly regulates multiple distinct molecular and cellular processes during early tendon cell differentiation
Proper development of tendons is crucial for the integration and function of the
musculoskeletal system. Currently little is known about the molecular mechanisms …
musculoskeletal system. Currently little is known about the molecular mechanisms …
[HTML][HTML] Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region
Y Li, Y Wei, M Ultsch, W Li, W Tang, B Tombling… - Nature …, 2024 - nature.com
Cystine-knot peptides (CKPs) are naturally occurring peptides that exhibit exceptional
chemical and proteolytic stability. We leveraged the CKP carboxypeptidase A1 inhibitor as a …
chemical and proteolytic stability. We leveraged the CKP carboxypeptidase A1 inhibitor as a …
[HTML][HTML] HtrA4 protease promotes chemotherapeutic-dependent cancer cell death
T Wenta, M Rychlowski, M Jarzab, B Lipinska - Cells, 2019 - mdpi.com
The HtrA4 human protease is crucial in placentation and embryo implantation, and its
altered level is connected with pre-eclampsia. The meta-analyses of microarray assays …
altered level is connected with pre-eclampsia. The meta-analyses of microarray assays …