Trypsin and chymotrypsin-like serine proteases from family S1 (clan PA) constitute the
largest protease group in humans and more generally in vertebrates. The prototypes …

Human HtrA1-4 proteins belong to the HtrA family of evolutionarily conserved serine
proteases and function as important modulators of many physiological processes, including …

The mammalian high temperature requirement A (HtrA) proteins are a family of
evolutionarily conserved serine proteases, consisting of four homologs (HtrA1-4) that are …

Lymphedema (LE) affects millions of people worldwide. It is a chronic progressive disease
with massive development of fibrosclerosis when untreated. There is no pharmacological …

The high temperature requirement factor A1 (HTRA1) is a serine protease which modulates
an array of signalling pathways driving basal biological processes. HTRA1 plays a …

The protease high temperature requirement A from the gastric pathogen Helicobacter pylori
(HtrA Hp) belongs to the well conserved family of serine proteases. HtrA Hp is an important …

The trimeric serine protease HTRA1 is a genetic risk factor associated with geographic
atrophy (GA), a currently untreatable form of age-related macular degeneration. Here, we …

Proper development of tendons is crucial for the integration and function of the
musculoskeletal system. Currently little is known about the molecular mechanisms …

Cystine-knot peptides (CKPs) are naturally occurring peptides that exhibit exceptional
chemical and proteolytic stability. We leveraged the CKP carboxypeptidase A1 inhibitor as a …

The HtrA4 human protease is crucial in placentation and embryo implantation, and its
altered level is connected with pre-eclampsia. The meta-analyses of microarray assays …