Peroxynitrite (PN; ONOO−) and its reactive oxygen precursor superoxide (SO; O2•−) are
critically important in the development of pain of several etiologies including pain associated …

Neurogenic inflammation is involved in skin inflammation. It is hypothesized that it is
involved in the pathogenesis of the common chronic cutaneous vascular disorder rosacea …

Background Sepsis remains a common and serious condition with significant morbidity and
mortality due to multiple organ dysfunction, especially acute lung injury (ALI) and acute …

α-Calcitonin gene–related peptide (αCGRP) is a vasodilator, but there is limited knowledge
of its long-term cardiovascular protective influence. We hypothesized that αCGRP protects …

The cold-induced vascular response, consisting of vasoconstriction followed by
vasodilatation, is critical for protecting the cutaneous tissues against cold injury. Whilst this …

The transient receptor potential vanilloid 1 (TRPV1) is primarily localized to sensory nerve
fibers and is associated with the stimulation of pain and inflammation. TRPV1 knockout …

Migraine is the most common form of headache disorder globally. The etiology of migraine is
multifactorial, with genetic components and environmental interactions considered to be the …

Aims The aim of the study is to investigate transient receptor potential ankyrin 1 (TRPA1)-
induced responses in the vasculature and on blood pressure and heart rate (HR), in …

Abstract Background and Purpose Transient receptor potential ankyrin‐1 (TRPA1) activation
is known to mediate neurogenic vasodilatation. We investigated the mechanisms involved in …

Obesity induced by Western diets is associated with type 2 diabetes mellitus and
cardiovascular diseases, although underlying mechanisms are unclear. We investigated a …