Background Triple-negative breast cancer (TNBC) is a heterogeneous, aggressive
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …

In the last century, we have seen a dramatic rise in the number of older persons globally, a
trend known as the grey (or silver) tsunami. People live markedly longer than their …

Antisense oligonucleotides (ASOs) are short single stranded synthetic RNA or DNA
molecules, whereas double-stranded RNA nucleotide sequences are called small …

In recent years, the use of immune checkpoint inhibitors (ICIs) in combination with approved
or experimental vaccines has proven to be a promising approach to improve vaccine …

Compared to other types of tumor vaccines, RNA vaccines have emerged as promising
alternatives to conventional vaccine therapy due to their high efficiency, rapid development …

During the current COVID-19 pandemic, the global ratio between the dead and the survivors
is approximately 1 to 10, which has put humanity on high alert and provided strong …

This review of the scientific and technological developments on New Genomic Techniques
(NGTs) is aimed to provide the technical status of NGTs with respect to their diverse …

The design of non-viral vectors that efficiently deliver genetic materials into cells, in
particular to the nucleus, remains a major challenge in gene therapy and vaccine …

The foundation of a biosimilar manufacturer's regulatory filing is the demonstration of
analytical and functional similarity between the biosimilar product and the pertinent …

Simple Summary Antisense oligonucleotide (ASO)-based drugs are a new class of
compounds. In this review, we will discuss ASO technology, including improved delivery …