Cancer immunotherapy and in particular monoclonal antibodies blocking the inhibitory
programed cell death 1 pathway (PD-1/PD-L1) have made a significant impact on the …

Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune
response. Although it was initially linked with the development of Th1 responses, it is now …

Recent genomic and biological studies of neuroblastoma have shed light on the dramatic
heterogeneity in the clinical behaviour of this disease, which spans from spontaneous …

It has been more than 15 years since the identification of individual interleukin-27 (IL-27)
and IL-27 receptor components. The last decade has seen the description of the signaling …

Review highlights the function of the cytokine receptor gp130, specifically the diverse roles it
plays in inflammation, autoimmunity, and cancer. Glycoprotein 130 (gp130) is a shared …

IL‐27 is a pleiotropic two‐chain cytokine, composed of EBI3 and IL‐27p28 subunits, which is
structurally related to both IL‐12 and IL‐6 cytokine families. IL‐27 acts through a …

The interleukin (IL)‐12 family, which is composed of heterodimeric cytokines including IL‐
12, IL‐23, and IL‐27, is produced by antigen‐presenting cells such as macrophages and …

IL-35 is a member of the IL-12 family of cytokines that is comprised of an IL-12 p35 subunit
and an IL-12 p40-related protein subunit, EBV-induced gene 3 (EBI3). IL-35 functions …

Neuroblastoma derived from primitive cells of the sympathetic nervous system typically
develops in the adrenal medulla or paraspinal ganglia. Neuroblastoma usually occurs …

Interleukin (IL)-27, a member of IL-12/IL-23 heterodimeric family of cytokines, has pleiotropic
properties that can enhance or limit immune responses. IL-27 acts on various cell types …